| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP6C | AGO2 | Ser831 | SAEGSHTsGQSNGRD | dephosphorylation up-regulates activity | 28114302 | SIGNOR-276513 |
| CSNK1A1 | AGO2 | Ser831 | SAEGSHTsGQSNGRD | phosphorylation down-regulates activity | 28114302 | SIGNOR-276508 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP6C | dephosphorylation down-regulates ⊣ | AGO2 PSer831 | dephosphorylation down-regulates ⊣ | AGO2 | 28114302 | SIGNOR-276513 |
| CSNK1A1 | phosphorylation up-regulates → | AGO2 PSer831 | phosphorylation down-regulates ⊣ | AGO2 | 28114302 | SIGNOR-276508 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP6C | dephosphorylation → up-regulates activity | AGO2 | SIGNOR-276513 |
| CSNK1A1 | phosphorylation → down-regulates activity | AGO2 | SIGNOR-276508 |
