Entity Details

Name EGFR_Tyr393
ID Q9UKV8
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN1AGO2Tyr393ASFNTDPyVREFGIMdephosphorylation
down-regulates activity		25175024SIGNOR-277120
EGFRAGO2Tyr393ASFNTDPyVREFGIMphosphorylation
up-regulates activity		25137592SIGNOR-278931
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPN1dephosphorylation
down-regulates
⊣
AGO2
PTyr393		dephosphorylation
up-regulates
→		AGO225175024SIGNOR-277120
EGFRphosphorylation
up-regulates
→
AGO2
PTyr393		phosphorylation
up-regulates
→		AGO225137592SIGNOR-278931
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN1dephosphorylation
→
down-regulates activity 		AGO2SIGNOR-277120
EGFRphosphorylation
→
up-regulates activity 		AGO2SIGNOR-278931