| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP6C | AGO2 | Ser828 | EHDSAEGsHTSGQSN | dephosphorylation up-regulates activity | 28114302 | SIGNOR-276517 |
| CSNK1A1 | AGO2 | Ser828 | EHDSAEGsHTSGQSN | phosphorylation down-regulates activity | 28114302 | SIGNOR-276512 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP6C | dephosphorylation down-regulates ⊣ | AGO2 PSer828 | dephosphorylation down-regulates ⊣ | AGO2 | 28114302 | SIGNOR-276517 |
| CSNK1A1 | phosphorylation up-regulates → | AGO2 PSer828 | phosphorylation down-regulates ⊣ | AGO2 | 28114302 | SIGNOR-276512 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP6C | dephosphorylation → up-regulates activity | AGO2 | SIGNOR-276517 |
| CSNK1A1 | phosphorylation → down-regulates activity | AGO2 | SIGNOR-276512 |