| Name | NUP50 |
| ID | Q9UKX7 |
| Role | substrate |
| Enzymatic Domains |
RanBD1 335-468 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | NUP50 | Ser221 | KVAAETQsPSLFGST | phosphorylation down-regulates activity | 19767751 | SIGNOR-188139 |
| MAPK3 | NUP50 | Ser221 | KVAAETQsPSLFGST | phosphorylation down-regulates | 19767751 | SIGNOR-188151 |
| MAPK3 | NUP50 | Ser315 | TQSKPVSsPFPTKPL | phosphorylation down-regulates activity | 19767751 | SIGNOR-187378 |
| CDK1 | NUP50 | Ser221 | KVAAETQsPSLFGST | phosphorylation down-regulates | 19767751 | SIGNOR-188061 |
| Gbeta | NUP50 | – | phosphorylation down-regulates | 19767751 | SIGNOR-270041 | |
| ERK1/2 | NUP50 | Ser221 | KVAAETQsPSLFGST | phosphorylation down-regulates activity | 19767751 | SIGNOR-188131 |
| MAPK1 | NUP50 | Ser315 | TQSKPVSsPFPTKPL | phosphorylation down-regulates activity | 19767751 | SIGNOR-188135 |
| ERK1/2 | NUP50 | Ser315 | TQSKPVSsPFPTKPL | phosphorylation down-regulates activity | 19767751 | SIGNOR-263043 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | NUP50 PSer221 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-188139 |
| MAPK3 | phosphorylation up-regulates → | NUP50 PSer221 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-188151 |
| MAPK3 | phosphorylation up-regulates → | NUP50 PSer315 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-187378 |
| CDK1 | phosphorylation up-regulates → | NUP50 PSer221 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-188061 |
| ERK1/2 | phosphorylation up-regulates → | NUP50 PSer221 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-188131 |
| MAPK1 | phosphorylation up-regulates → | NUP50 PSer315 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-188135 |
| ERK1/2 | phosphorylation up-regulates → | NUP50 PSer315 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-263043 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → down-regulates activity | NUP50 | SIGNOR-188139 |
| MAPK3 | phosphorylation down-regulates | NUP50 | SIGNOR-188151 |
| MAPK3 | phosphorylation → down-regulates activity | NUP50 | SIGNOR-187378 |
| CDK1 | phosphorylation down-regulates | NUP50 | SIGNOR-188061 |
| Gbeta | phosphorylation down-regulates | NUP50 | SIGNOR-270041 |
| ERK1/2 | phosphorylation → down-regulates activity | NUP50 | SIGNOR-188131 |
| MAPK1 | phosphorylation → down-regulates activity | NUP50 | SIGNOR-188135 |
| ERK1/2 | phosphorylation → down-regulates activity | NUP50 | SIGNOR-263043 |