| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | NUP50 | Ser221 | KVAAETQsPSLFGST | phosphorylation down-regulates activity | 19767751 | SIGNOR-188131 |
| MAPK1 | NUP50 | Ser221 | KVAAETQsPSLFGST | phosphorylation down-regulates activity | 19767751 | SIGNOR-188139 |
| MAPK3 | NUP50 | Ser221 | KVAAETQsPSLFGST | phosphorylation down-regulates | 19767751 | SIGNOR-188151 |
| CDK1 | NUP50 | Ser221 | KVAAETQsPSLFGST | phosphorylation down-regulates | 19767751 | SIGNOR-188061 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | NUP50 PSer221 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-188131 |
| MAPK1 | phosphorylation up-regulates → | NUP50 PSer221 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-188139 |
| MAPK3 | phosphorylation up-regulates → | NUP50 PSer221 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-188151 |
| CDK1 | phosphorylation up-regulates → | NUP50 PSer221 | phosphorylation down-regulates ⊣ | NUP50 | 19767751 | SIGNOR-188061 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation → down-regulates activity | NUP50 | SIGNOR-188131 |
| MAPK1 | phosphorylation → down-regulates activity | NUP50 | SIGNOR-188139 |
| MAPK3 | phosphorylation down-regulates | NUP50 | SIGNOR-188151 |
| CDK1 | phosphorylation down-regulates | NUP50 | SIGNOR-188061 |
