| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG2 | HCN2 | Ser668 | DRIGKKNsILLHKVQ | phosphorylation down-regulates activity | 21347269 | SIGNOR-263185 |
| SRC | HCN2 | Tyr476 | LDSSRRQyQEKYKQV | phosphorylation up-regulates activity | 26280531 | SIGNOR-263199 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG2 | phosphorylation up-regulates → | HCN2 PSer668 | phosphorylation down-regulates ⊣ | HCN2 | 21347269 | SIGNOR-263185 |
| SRC | phosphorylation up-regulates → | HCN2 PTyr476 | phosphorylation up-regulates → | HCN2 | 26280531 | SIGNOR-263199 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKG2 | phosphorylation → down-regulates activity | HCN2 | SIGNOR-263185 |
| SRC | phosphorylation → up-regulates activity | HCN2 | SIGNOR-263199 |
