| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | TRPC5 | Ser796 | GARAKSKsVSFNLGC | phosphorylation down-regulates activity | 21734191 | SIGNOR-276339 |
| PKA | TRPC5 | Ser794 | SGGARAKsKSVSFNL | phosphorylation down-regulates activity | 21734191 | SIGNOR-276340 |
| PKA | TRPC5 | Ser794 | SGGARAKsKSVSFNL | phosphorylation down-regulates activity | 21734191 | SIGNOR-273790 |
| PRKACA | TRPC5 | Ser794 | SGGARAKsKSVSFNL | phosphorylation down-regulates quantity | 21734191 | SIGNOR-277823 |
| PKA | TRPC5 | Ser796 | GARAKSKsVSFNLGC | phosphorylation down-regulates activity | 21734191 | SIGNOR-273789 |
| PKA | TRPC5 | Ser796 | GARAKSKsVSFNLGC | phosphorylation down-regulates quantity | 21734191 | SIGNOR-277824 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | TRPC5 PSer796 | phosphorylation down-regulates ⊣ | TRPC5 | 21734191 | SIGNOR-276339 |
| PKA | phosphorylation up-regulates → | TRPC5 PSer794 | phosphorylation down-regulates ⊣ | TRPC5 | 21734191 | SIGNOR-276340 |
| PKA | phosphorylation up-regulates → | TRPC5 PSer794 | phosphorylation down-regulates ⊣ | TRPC5 | 21734191 | SIGNOR-273790 |
| PRKACA | phosphorylation up-regulates → | TRPC5 PSer794 | phosphorylation down-regulates ⊣ | TRPC5 | 21734191 | SIGNOR-277823 |
| PKA | phosphorylation up-regulates → | TRPC5 PSer796 | phosphorylation down-regulates ⊣ | TRPC5 | 21734191 | SIGNOR-273789 |
| PKA | phosphorylation up-regulates → | TRPC5 PSer796 | phosphorylation down-regulates ⊣ | TRPC5 | 21734191 | SIGNOR-277824 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → down-regulates activity | TRPC5 | SIGNOR-276339 |
| PKA | phosphorylation → down-regulates activity | TRPC5 | SIGNOR-276340 |
| PKA | phosphorylation → down-regulates activity | TRPC5 | SIGNOR-273790 |
| PRKACA | phosphorylation → down-regulates quantity | TRPC5 | SIGNOR-277823 |
| PKA | phosphorylation → down-regulates activity | TRPC5 | SIGNOR-273789 |
| PKA | phosphorylation → down-regulates quantity | TRPC5 | SIGNOR-277824 |