Entity Details

Name TPX2
ID Q9ULW0
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AURKATPX2Ser125
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QRRSLRLsAQKDLEQphosphorylation
up-regulates activity		26240182SIGNOR-265088
CDK5TPX2Ser486
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LPITVPKsPAFALKNphosphorylation
up-regulates quantity by stabilization		31272499SIGNOR-265100
CDK1TPX2Thr72
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NLQQAIVtPLKPVDNphosphorylation
down-regulates activity		25688093SIGNOR-265096
CDK2TPX2Thr72
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NLQQAIVtPLKPVDNphosphorylation
down-regulates activity		25688093SIGNOR-265099
AURKATPX2Ser121
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PAQPQRRsLRLSAQKphosphorylation
up-regulates activity		26240182SIGNOR-265089
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AURKAphosphorylation
up-regulates
→
TPX2
PSer125		phosphorylation
up-regulates
→		TPX226240182SIGNOR-265088
CDK5phosphorylation
up-regulates
→
TPX2
PSer486		phosphorylation
up-regulates
→		TPX231272499SIGNOR-265100
CDK1phosphorylation
up-regulates
→
TPX2
PThr72		phosphorylation
down-regulates
⊣		TPX225688093SIGNOR-265096
CDK2phosphorylation
up-regulates
→
TPX2
PThr72		phosphorylation
down-regulates
⊣		TPX225688093SIGNOR-265099
AURKAphosphorylation
up-regulates
→
TPX2
PSer121		phosphorylation
up-regulates
→		TPX226240182SIGNOR-265089
Regulator Mechanism/Effect Target SIGNOR-ID
AURKAphosphorylation
→
up-regulates activity 		TPX2SIGNOR-265088
CDK5phosphorylation
→
up-regulates quantity by stabilization 		TPX2SIGNOR-265100
CDK1phosphorylation
→
down-regulates activity 		TPX2SIGNOR-265096
CDK2phosphorylation
→
down-regulates activity 		TPX2SIGNOR-265099
AURKAphosphorylation
→
up-regulates activity 		TPX2SIGNOR-265089