| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | NDRG2 | Ser332 | LSRSRTAsLTSAASV | phosphorylation up-regulates | 15461589 | SIGNOR-129672 |
| DAPK1 | NDRG2 | – | phosphorylation up-regulates activity | 32500074 | SIGNOR-279983 | |
| SGK1 | NDRG2 | Thr348 | GNRSRSRtLSQSSES | phosphorylation up-regulates | 15461589 | SIGNOR-129680 |
| SGK1 | NDRG2 | Thr330 | TRLSRSRtASLTSAA | phosphorylation up-regulates | 15461589 | SIGNOR-129676 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | phosphorylation up-regulates → | NDRG2 PSer332 | phosphorylation up-regulates → | NDRG2 | 15461589 | SIGNOR-129672 |
| SGK1 | phosphorylation up-regulates → | NDRG2 PThr348 | phosphorylation up-regulates → | NDRG2 | 15461589 | SIGNOR-129680 |
| SGK1 | phosphorylation up-regulates → | NDRG2 PThr330 | phosphorylation up-regulates → | NDRG2 | 15461589 | SIGNOR-129676 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SGK1 | phosphorylation → up-regulates | NDRG2 | SIGNOR-129672 |
| DAPK1 | phosphorylation → up-regulates activity | NDRG2 | SIGNOR-279983 |
| SGK1 | phosphorylation → up-regulates | NDRG2 | SIGNOR-129680 |
| SGK1 | phosphorylation → up-regulates | NDRG2 | SIGNOR-129676 |