| Name | CILK1 |
| ID | Q9UPZ9 |
| Role | substrate |
| Enzymatic Domains |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP5C | CILK1 | Thr157 | IRSKPPYtDYVSTRW | dephosphorylation down-regulates activity | 16954377 | SIGNOR-248541 |
| CDK20 | CILK1 | Thr157 | IRSKPPYtDYVSTRW | phosphorylation up-regulates | 15988018 | SIGNOR-138420 |
| FGFR3 | CILK1 | Tyr15 | RQLGDGTyGSVLLGR | phosphorylation down-regulates activity | 30782830 | SIGNOR-277436 |
| PPP2CA | CILK1 | Thr157 | IRSKPPYtDYVSTRW | dephosphorylation down-regulates | 15988018 | SIGNOR-138428 |
| PPP2CA | CILK1 | Tyr159 | SKPPYTDyVSTRWYR | dephosphorylation down-regulates | 15988018 | SIGNOR-138432 |
| CILK1 | CILK1 | Tyr159 | SKPPYTDyVSTRWYR | phosphorylation up-regulates | 15988018 | SIGNOR-138424 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP5C | dephosphorylation down-regulates ⊣ | CILK1 PThr157 | dephosphorylation up-regulates → | CILK1 | 16954377 | SIGNOR-248541 |
| CDK20 | phosphorylation up-regulates → | CILK1 PThr157 | phosphorylation up-regulates → | CILK1 | 15988018 | SIGNOR-138420 |
| FGFR3 | phosphorylation up-regulates → | CILK1 PTyr15 | phosphorylation down-regulates ⊣ | CILK1 | 30782830 | SIGNOR-277436 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CILK1 PThr157 | dephosphorylation up-regulates → | CILK1 | 15988018 | SIGNOR-138428 |
| PPP2CA | dephosphorylation down-regulates ⊣ | CILK1 PTyr159 | dephosphorylation up-regulates → | CILK1 | 15988018 | SIGNOR-138432 |
| CILK1 | phosphorylation up-regulates → | CILK1 PTyr159 | phosphorylation up-regulates → | CILK1 | 15988018 | SIGNOR-138424 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP5C | dephosphorylation → down-regulates activity | CILK1 | SIGNOR-248541 |
| CDK20 | phosphorylation → up-regulates | CILK1 | SIGNOR-138420 |
| FGFR3 | phosphorylation → down-regulates activity | CILK1 | SIGNOR-277436 |
| PPP2CA | dephosphorylation down-regulates | CILK1 | SIGNOR-138428 |
| PPP2CA | dephosphorylation down-regulates | CILK1 | SIGNOR-138432 |
| CILK1 | phosphorylation → up-regulates | CILK1 | SIGNOR-138424 |