| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | CILK1 | Thr157 | IRSKPPYtDYVSTRW | dephosphorylation down-regulates | 15988018 | SIGNOR-138428 |
| PPP5C | CILK1 | Thr157 | IRSKPPYtDYVSTRW | dephosphorylation down-regulates activity | 16954377 | SIGNOR-248541 |
| CDK20 | CILK1 | Thr157 | IRSKPPYtDYVSTRW | phosphorylation up-regulates | 15988018 | SIGNOR-138420 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | CILK1 PThr157 | dephosphorylation up-regulates → | CILK1 | 15988018 | SIGNOR-138428 |
| PPP5C | dephosphorylation down-regulates ⊣ | CILK1 PThr157 | dephosphorylation up-regulates → | CILK1 | 16954377 | SIGNOR-248541 |
| CDK20 | phosphorylation up-regulates → | CILK1 PThr157 | phosphorylation up-regulates → | CILK1 | 15988018 | SIGNOR-138420 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates | CILK1 | SIGNOR-138428 |
| PPP5C | dephosphorylation → down-regulates activity | CILK1 | SIGNOR-248541 |
| CDK20 | phosphorylation → up-regulates | CILK1 | SIGNOR-138420 |
