| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | CILK1 | Tyr159 | SKPPYTDyVSTRWYR | dephosphorylation down-regulates | 15988018 | SIGNOR-138432 |
| CILK1 | CILK1 | Tyr159 | SKPPYTDyVSTRWYR | phosphorylation up-regulates | 15988018 | SIGNOR-138424 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | CILK1 PTyr159 | dephosphorylation up-regulates → | CILK1 | 15988018 | SIGNOR-138432 |
| CILK1 | phosphorylation up-regulates → | CILK1 PTyr159 | phosphorylation up-regulates → | CILK1 | 15988018 | SIGNOR-138424 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates | CILK1 | SIGNOR-138432 |
| CILK1 | phosphorylation → up-regulates | CILK1 | SIGNOR-138424 |
