| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | SHOC2 | Ser297 | GLRYNRLsAIPRSLA | phosphorylation down-regulates quantity by destabilization | 29383184 | SIGNOR-275567 |
| PRKCA | SHOC2 | Thr71 | VAFSVDNtIKRPNPA | phosphorylation down-regulates quantity by destabilization | 29383184 | SIGNOR-275568 |
| PRKCD | SHOC2 | Ser297 | GLRYNRLsAIPRSLA | phosphorylation down-regulates quantity by destabilization | 29383184 | SIGNOR-275565 |
| MAPK3 | SHOC2 | Thr507 | GLGENLLtHLPEEIG | phosphorylation down-regulates quantity by destabilization | 30865892 | SIGNOR-277443 |
| MAPK1 | SHOC2 | Thr507 | GLGENLLtHLPEEIG | phosphorylation down-regulates quantity by destabilization | 30865892 | SIGNOR-277442 |
| PRKCD | SHOC2 | Thr71 | VAFSVDNtIKRPNPA | phosphorylation down-regulates quantity by destabilization | 29383184 | SIGNOR-275564 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | SHOC2 PSer297 | phosphorylation down-regulates ⊣ | SHOC2 | 29383184 | SIGNOR-275567 |
| PRKCA | phosphorylation up-regulates → | SHOC2 PThr71 | phosphorylation down-regulates ⊣ | SHOC2 | 29383184 | SIGNOR-275568 |
| PRKCD | phosphorylation up-regulates → | SHOC2 PSer297 | phosphorylation down-regulates ⊣ | SHOC2 | 29383184 | SIGNOR-275565 |
| MAPK3 | phosphorylation up-regulates → | SHOC2 PThr507 | phosphorylation down-regulates ⊣ | SHOC2 | 30865892 | SIGNOR-277443 |
| MAPK1 | phosphorylation up-regulates → | SHOC2 PThr507 | phosphorylation down-regulates ⊣ | SHOC2 | 30865892 | SIGNOR-277442 |
| PRKCD | phosphorylation up-regulates → | SHOC2 PThr71 | phosphorylation down-regulates ⊣ | SHOC2 | 29383184 | SIGNOR-275564 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation down-regulates quantity by destabilization | SHOC2 | SIGNOR-275567 |
| PRKCA | phosphorylation down-regulates quantity by destabilization | SHOC2 | SIGNOR-275568 |
| PRKCD | phosphorylation down-regulates quantity by destabilization | SHOC2 | SIGNOR-275565 |
| MAPK3 | phosphorylation down-regulates quantity by destabilization | SHOC2 | SIGNOR-277443 |
| MAPK1 | phosphorylation down-regulates quantity by destabilization | SHOC2 | SIGNOR-277442 |
| PRKCD | phosphorylation down-regulates quantity by destabilization | SHOC2 | SIGNOR-275564 |
