| Name | GAB2 |
| ID | Q9UQC2 |
| Role | substrate |
| Enzymatic Domains |
PH 6-117 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | GAB2 | Ser623 | ALDFQPSsPSPHRKP | phosphorylation up-regulates | 15356145 | SIGNOR-128727 |
| AKT1 | GAB2 | Ser159 | LLRERKSsAPSHSSQ | phosphorylation down-regulates | 11782427 | SIGNOR-252468 |
| JAK2 | GAB2 | Tyr643 | TSDEKVDyVQVDKEK | phosphorylation up-regulates | 18644434 | SIGNOR-179488 |
| ERK1/2 | GAB2 | – | phosphorylation up-regulates | 15356145 | SIGNOR-270133 | |
| Gbeta | GAB2 | – | phosphorylation up-regulates | 15356145 | SIGNOR-270000 | |
| ZAP70 | GAB2 | Tyr614 | KSTGSVDyLALDFQP | phosphorylation up-regulates activity | 11572860 | SIGNOR-110731 |
| FYN | GAB2 | – | phosphorylation up-regulates activity | 33827252 | SIGNOR-279984 | |
| AKT | GAB2 | Ser159 | LLRERKSsAPSHSSQ | phosphorylation down-regulates | 11782427 | SIGNOR-113669 |
| PTPN11 | GAB2 | Tyr614 | KSTGSVDyLALDFQP | dephosphorylation down-regulates | 15170389 | SIGNOR-124958 |
| MAPK3 | GAB2 | Ser623 | ALDFQPSsPSPHRKP | phosphorylation up-regulates | 15356145 | SIGNOR-128731 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | GAB2 PSer623 | phosphorylation up-regulates → | GAB2 | 15356145 | SIGNOR-128727 |
| AKT1 | phosphorylation up-regulates → | GAB2 PSer159 | phosphorylation down-regulates ⊣ | GAB2 | 11782427 | SIGNOR-252468 |
| JAK2 | phosphorylation up-regulates → | GAB2 PTyr643 | phosphorylation up-regulates → | GAB2 | 18644434 | SIGNOR-179488 |
| ZAP70 | phosphorylation up-regulates → | GAB2 PTyr614 | phosphorylation up-regulates → | GAB2 | 11572860 | SIGNOR-110731 |
| AKT | phosphorylation up-regulates → | GAB2 PSer159 | phosphorylation down-regulates ⊣ | GAB2 | 11782427 | SIGNOR-113669 |
| PTPN11 | dephosphorylation down-regulates ⊣ | GAB2 PTyr614 | dephosphorylation up-regulates → | GAB2 | 15170389 | SIGNOR-124958 |
| MAPK3 | phosphorylation up-regulates → | GAB2 PSer623 | phosphorylation up-regulates → | GAB2 | 15356145 | SIGNOR-128731 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates | GAB2 | SIGNOR-128727 |
| AKT1 | phosphorylation down-regulates | GAB2 | SIGNOR-252468 |
| JAK2 | phosphorylation → up-regulates | GAB2 | SIGNOR-179488 |
| ERK1/2 | phosphorylation → up-regulates | GAB2 | SIGNOR-270133 |
| Gbeta | phosphorylation → up-regulates | GAB2 | SIGNOR-270000 |
| ZAP70 | phosphorylation → up-regulates activity | GAB2 | SIGNOR-110731 |
| FYN | phosphorylation → up-regulates activity | GAB2 | SIGNOR-279984 |
| AKT | phosphorylation down-regulates | GAB2 | SIGNOR-113669 |
| PTPN11 | dephosphorylation down-regulates | GAB2 | SIGNOR-124958 |
| MAPK3 | phosphorylation → up-regulates | GAB2 | SIGNOR-128731 |