Entity Details

Name PTPN11_Tyr614
ID Q9UQC2
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ZAP70GAB2Tyr614KSTGSVDyLALDFQPphosphorylation
up-regulates activity		11572860SIGNOR-110731
PTPN11GAB2Tyr614KSTGSVDyLALDFQPdephosphorylation
down-regulates		15170389SIGNOR-124958
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ZAP70phosphorylation
up-regulates
→
GAB2
PTyr614		phosphorylation
up-regulates
→		GAB211572860SIGNOR-110731
PTPN11dephosphorylation
down-regulates
⊣
GAB2
PTyr614		dephosphorylation
up-regulates
→		GAB215170389SIGNOR-124958
Regulator Mechanism/Effect Target SIGNOR-ID
ZAP70phosphorylation
→
up-regulates activity 		GAB2SIGNOR-110731
PTPN11dephosphorylation
img/direct_inhibition.png
down-regulates 		GAB2SIGNOR-124958