| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation down-regulates | 21892142 | SIGNOR-216596 |
| CAMK1 | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation down-regulates | 11114197 | SIGNOR-85018 |
| PRKD2 | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation up-regulates activity | 18692497 | SIGNOR-275929 |
| CAMK4 | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation down-regulates | 11114197 | SIGNOR-85106 |
| CAMK2G | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation down-regulates | 11114197 | SIGNOR-85102 |
| PRKD2 | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation up-regulates activity | 18692497 | SIGNOR-275927 |
| DYRK1B | HDAC5 | Ser279 | KVAERRSsPLLRRKD | phosphorylation down-regulates activity | 15546868 | SIGNOR-235809 |
| PRKAA1 | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation down-regulates | 21892142 | SIGNOR-176479 |
| AMPK | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation down-regulates | 21892142 | SIGNOR-216550 |
| GRK5 | HDAC5 | – | phosphorylation down-regulates activity | 23658733 | SIGNOR-279045 | |
| CAMK1 | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation down-regulates | 11114197 | SIGNOR-85022 |
| PRKCD | HDAC5 | Ser498 | RHRPLSRtQSSPLPQ | phosphorylation down-regulates activity | 18332134 | SIGNOR-260876 |
| CAMK4 | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation down-regulates | 12058061 | SIGNOR-236571 |
| CAMK2G | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation down-regulates | 11114197 | SIGNOR-85098 |
| PRKD3 | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation up-regulates activity | 18692497 | SIGNOR-275926 |
| PRKCD | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation down-regulates activity | 18332134 | SIGNOR-260875 |
| PRKCA | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation down-regulates activity | 15367659 | SIGNOR-249269 |
| PRKACA | HDAC5 | Ser279 | KVAERRSsPLLRRKD | phosphorylation up-regulates activity | 22865920 | SIGNOR-198658 |
| PRKCA | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation down-regulates activity | 15367659 | SIGNOR-249268 |
| CAMK4 | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation down-regulates | 12058061 | SIGNOR-236575 |
| PRKD1 | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation down-regulates activity | 15367659 | SIGNOR-249270 |
| AURKB | HDAC5 | Ser278 | QKVAERRsSPLLRRK | phosphorylation down-regulates | 22865920 | SIGNOR-198650 |
| PRKD3 | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation up-regulates activity | 18692497 | SIGNOR-275928 |
| CAMK4 | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation down-regulates | 11114197 | SIGNOR-85110 |
| PRKAA1 | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation down-regulates | 21892142 | SIGNOR-176483 |
| PRKD1 | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation down-regulates | 22865920 | SIGNOR-198662 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation down-regulates ⊣ | HDAC5 | 21892142 | SIGNOR-216596 |
| CAMK1 | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation down-regulates ⊣ | HDAC5 | 11114197 | SIGNOR-85018 |
| PRKD2 | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation up-regulates → | HDAC5 | 18692497 | SIGNOR-275929 |
| CAMK4 | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation down-regulates ⊣ | HDAC5 | 11114197 | SIGNOR-85106 |
| CAMK2G | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation down-regulates ⊣ | HDAC5 | 11114197 | SIGNOR-85102 |
| PRKD2 | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation up-regulates → | HDAC5 | 18692497 | SIGNOR-275927 |
| DYRK1B | phosphorylation up-regulates → | HDAC5 PSer279 | phosphorylation down-regulates ⊣ | HDAC5 | 15546868 | SIGNOR-235809 |
| PRKAA1 | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation down-regulates ⊣ | HDAC5 | 21892142 | SIGNOR-176479 |
| AMPK | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation down-regulates ⊣ | HDAC5 | 21892142 | SIGNOR-216550 |
| CAMK1 | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation down-regulates ⊣ | HDAC5 | 11114197 | SIGNOR-85022 |
| PRKCD | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation down-regulates ⊣ | HDAC5 | 18332134 | SIGNOR-260876 |
| CAMK4 | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation down-regulates ⊣ | HDAC5 | 12058061 | SIGNOR-236571 |
| CAMK2G | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation down-regulates ⊣ | HDAC5 | 11114197 | SIGNOR-85098 |
| PRKD3 | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation up-regulates → | HDAC5 | 18692497 | SIGNOR-275926 |
| PRKCD | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation down-regulates ⊣ | HDAC5 | 18332134 | SIGNOR-260875 |
| PRKCA | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation down-regulates ⊣ | HDAC5 | 15367659 | SIGNOR-249269 |
| PRKACA | phosphorylation up-regulates → | HDAC5 PSer279 | phosphorylation up-regulates → | HDAC5 | 22865920 | SIGNOR-198658 |
| PRKCA | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation down-regulates ⊣ | HDAC5 | 15367659 | SIGNOR-249268 |
| CAMK4 | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation down-regulates ⊣ | HDAC5 | 12058061 | SIGNOR-236575 |
| PRKD1 | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation down-regulates ⊣ | HDAC5 | 15367659 | SIGNOR-249270 |
| AURKB | phosphorylation up-regulates → | HDAC5 PSer278 | phosphorylation down-regulates ⊣ | HDAC5 | 22865920 | SIGNOR-198650 |
| PRKD3 | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation up-regulates → | HDAC5 | 18692497 | SIGNOR-275928 |
| CAMK4 | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation down-regulates ⊣ | HDAC5 | 11114197 | SIGNOR-85110 |
| PRKAA1 | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation down-regulates ⊣ | HDAC5 | 21892142 | SIGNOR-176483 |
| PRKD1 | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation down-regulates ⊣ | HDAC5 | 22865920 | SIGNOR-198662 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation down-regulates | HDAC5 | SIGNOR-216596 |
| CAMK1 | phosphorylation down-regulates | HDAC5 | SIGNOR-85018 |
| PRKD2 | phosphorylation → up-regulates activity | HDAC5 | SIGNOR-275929 |
| CAMK4 | phosphorylation down-regulates | HDAC5 | SIGNOR-85106 |
| CAMK2G | phosphorylation down-regulates | HDAC5 | SIGNOR-85102 |
| PRKD2 | phosphorylation → up-regulates activity | HDAC5 | SIGNOR-275927 |
| DYRK1B | phosphorylation → down-regulates activity | HDAC5 | SIGNOR-235809 |
| PRKAA1 | phosphorylation down-regulates | HDAC5 | SIGNOR-176479 |
| AMPK | phosphorylation down-regulates | HDAC5 | SIGNOR-216550 |
| GRK5 | phosphorylation → down-regulates activity | HDAC5 | SIGNOR-279045 |
| CAMK1 | phosphorylation down-regulates | HDAC5 | SIGNOR-85022 |
| PRKCD | phosphorylation → down-regulates activity | HDAC5 | SIGNOR-260876 |
| CAMK4 | phosphorylation down-regulates | HDAC5 | SIGNOR-236571 |
| CAMK2G | phosphorylation down-regulates | HDAC5 | SIGNOR-85098 |
| PRKD3 | phosphorylation → up-regulates activity | HDAC5 | SIGNOR-275926 |
| PRKCD | phosphorylation → down-regulates activity | HDAC5 | SIGNOR-260875 |
| PRKCA | phosphorylation → down-regulates activity | HDAC5 | SIGNOR-249269 |
| PRKACA | phosphorylation → up-regulates activity | HDAC5 | SIGNOR-198658 |
| PRKCA | phosphorylation → down-regulates activity | HDAC5 | SIGNOR-249268 |
| CAMK4 | phosphorylation down-regulates | HDAC5 | SIGNOR-236575 |
| PRKD1 | phosphorylation → down-regulates activity | HDAC5 | SIGNOR-249270 |
| AURKB | phosphorylation down-regulates | HDAC5 | SIGNOR-198650 |
| PRKD3 | phosphorylation → up-regulates activity | HDAC5 | SIGNOR-275928 |
| CAMK4 | phosphorylation down-regulates | HDAC5 | SIGNOR-85110 |
| PRKAA1 | phosphorylation down-regulates | HDAC5 | SIGNOR-176483 |
| PRKD1 | phosphorylation down-regulates | HDAC5 | SIGNOR-198662 |
