| Name | SH2B3 |
| ID | Q9UQQ2 |
| Role | substrate |
| Enzymatic Domains |
PH 194-307
SH2 364-462 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | SH2B3 | Tyr273 | LEMPDNLyTFVLKVK | phosphorylation up-regulates | 9169414 | SIGNOR-48850 |
| ZAP70 | SH2B3 | Tyr273 | LEMPDNLyTFVLKVK | phosphorylation up-regulates | 9169414 | SIGNOR-48854 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | SH2B3 PTyr273 | phosphorylation up-regulates → | SH2B3 | 9169414 | SIGNOR-48850 |
| ZAP70 | phosphorylation up-regulates → | SH2B3 PTyr273 | phosphorylation up-regulates → | SH2B3 | 9169414 | SIGNOR-48854 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → up-regulates | SH2B3 | SIGNOR-48850 |
| ZAP70 | phosphorylation → up-regulates | SH2B3 | SIGNOR-48854 |