Entity Details

Name TRPC6
ID Q9Y210
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
FYNTRPC6–phosphorylation
up-regulates activity		21471003SIGNOR-279717
SRCTRPC6Tyr31RRNESQDyLLMDSELphosphorylation
up-regulates activity		21471003SIGNOR-279659
PRKG1TRPC6Ser322KNDYKKLsMQCKDFVphosphorylation
down-regulates activity		19961855SIGNOR-276271
PRKG1TRPC6Thr70RLAHRRQtVLREKGRphosphorylation
down-regulates activity		19961855SIGNOR-276272
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
SRCphosphorylation
up-regulates
→
TRPC6
PTyr31		phosphorylation
up-regulates
→		TRPC621471003SIGNOR-279659
PRKG1phosphorylation
up-regulates
→
TRPC6
PSer322		phosphorylation
down-regulates
⊣		TRPC619961855SIGNOR-276271
PRKG1phosphorylation
up-regulates
→
TRPC6
PThr70		phosphorylation
down-regulates
⊣		TRPC619961855SIGNOR-276272
Regulator Mechanism/Effect Target SIGNOR-ID
FYNphosphorylation
→
up-regulates activity 		TRPC6SIGNOR-279717
SRCphosphorylation
→
up-regulates activity 		TRPC6SIGNOR-279659
PRKG1phosphorylation
→
down-regulates activity 		TRPC6SIGNOR-276271
PRKG1phosphorylation
→
down-regulates activity 		TRPC6SIGNOR-276272