| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | FOXA2 | – | phosphorylation down-regulates | 14500912 | SIGNOR-254978 | |
| CHUK | FOXA2 | Ser111 | PHLSPSLsPLGGQAA | phosphorylation down-regulates | 22196886 | SIGNOR-195316 |
| AKT | FOXA2 | Thr156 | KTYRRSYtHAKPPYS | phosphorylation down-regulates activity | 14500912 | SIGNOR-254974 |
| CHUK | FOXA2 | Ser107 | AGMGPHLsPSLSPLG | phosphorylation down-regulates | 22196886 | SIGNOR-195312 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHUK | phosphorylation up-regulates → | FOXA2 PSer111 | phosphorylation down-regulates ⊣ | FOXA2 | 22196886 | SIGNOR-195316 |
| AKT | phosphorylation up-regulates → | FOXA2 PThr156 | phosphorylation down-regulates ⊣ | FOXA2 | 14500912 | SIGNOR-254974 |
| CHUK | phosphorylation up-regulates → | FOXA2 PSer107 | phosphorylation down-regulates ⊣ | FOXA2 | 22196886 | SIGNOR-195312 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation down-regulates | FOXA2 | SIGNOR-254978 |
| CHUK | phosphorylation down-regulates | FOXA2 | SIGNOR-195316 |
| AKT | phosphorylation → down-regulates activity | FOXA2 | SIGNOR-254974 |
| CHUK | phosphorylation down-regulates | FOXA2 | SIGNOR-195312 |
