| Name | NINL |
| ID | Q9Y2I6 |
| Role | substrate |
| Enzymatic Domains |
EF-hand 1 7-42 PROSITE-ProRule
EF-hand 2 41-76 PROSITE-ProRule
EF-hand 3 196-231 PROSITE-ProRule
EF-hand 4 233-268 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | NINL | Ser185 | WDSEDFGsPQKSCSP | phosphorylation up-regulates | 20864540 | SIGNOR-168045 |
| PLK1 | NINL | Ser87 | VRPSDEDsSSLESAA | phosphorylation down-regulates activity | 12852856 | SIGNOR-103352 |
| AURKB | NINL | Ser448 | QGYRERLsLLRSEVE | phosphorylation up-regulates | 20864540 | SIGNOR-168049 |
| CDK1 | NINL | Ser589 | NRHSPSWsPDGRRRQ | phosphorylation down-regulates quantity by destabilization | 20890132 | SIGNOR-259831 |
| PLK1 | NINL | Ser88 | RPSDEDSsSLESAAS | phosphorylation down-regulates activity | 12852856 | SIGNOR-103356 |
| PLK1 | NINL | Thr161 | SDEEAEStKEAQNEL | phosphorylation down-regulates activity | 12852856 | SIGNOR-103364 |
| AURKB | NINL | Ser585 | RLPKNRHsPSWSPDG | phosphorylation up-regulates | 20864540 | SIGNOR-168053 |
| PLK1 | NINL | Ser686 | LEELHEKsQEVIWGL | phosphorylation down-regulates activity | 12852856 | SIGNOR-103348 |
| CDK1 | NINL | Ser185 | NRHSPSWsPDGRRRQ | phosphorylation up-regulates activity | 20890132 | SIGNOR-259830 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | phosphorylation up-regulates → | NINL PSer185 | phosphorylation up-regulates → | NINL | 20864540 | SIGNOR-168045 |
| PLK1 | phosphorylation up-regulates → | NINL PSer87 | phosphorylation down-regulates ⊣ | NINL | 12852856 | SIGNOR-103352 |
| AURKB | phosphorylation up-regulates → | NINL PSer448 | phosphorylation up-regulates → | NINL | 20864540 | SIGNOR-168049 |
| CDK1 | phosphorylation up-regulates → | NINL PSer589 | phosphorylation down-regulates ⊣ | NINL | 20890132 | SIGNOR-259831 |
| PLK1 | phosphorylation up-regulates → | NINL PSer88 | phosphorylation down-regulates ⊣ | NINL | 12852856 | SIGNOR-103356 |
| PLK1 | phosphorylation up-regulates → | NINL PThr161 | phosphorylation down-regulates ⊣ | NINL | 12852856 | SIGNOR-103364 |
| AURKB | phosphorylation up-regulates → | NINL PSer585 | phosphorylation up-regulates → | NINL | 20864540 | SIGNOR-168053 |
| PLK1 | phosphorylation up-regulates → | NINL PSer686 | phosphorylation down-regulates ⊣ | NINL | 12852856 | SIGNOR-103348 |
| CDK1 | phosphorylation up-regulates → | NINL PSer185 | phosphorylation up-regulates → | NINL | 20890132 | SIGNOR-259830 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKB | phosphorylation → up-regulates | NINL | SIGNOR-168045 |
| PLK1 | phosphorylation → down-regulates activity | NINL | SIGNOR-103352 |
| AURKB | phosphorylation → up-regulates | NINL | SIGNOR-168049 |
| CDK1 | phosphorylation down-regulates quantity by destabilization | NINL | SIGNOR-259831 |
| PLK1 | phosphorylation → down-regulates activity | NINL | SIGNOR-103356 |
| PLK1 | phosphorylation → down-regulates activity | NINL | SIGNOR-103364 |
| AURKB | phosphorylation → up-regulates | NINL | SIGNOR-168053 |
| PLK1 | phosphorylation → down-regulates activity | NINL | SIGNOR-103348 |
| CDK1 | phosphorylation → up-regulates activity | NINL | SIGNOR-259830 |