Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
SGK3	PIKFYVE	Ser318	LSLDRSGsPMVPSYE	phosphorylation up-regulates activity	22470488	SIGNOR-279113
AMPK	PIKFYVE	Ser307 View in OncoXplorer	PARNRSAsITNLSLD	phosphorylation up-regulates activity	23905686	SIGNOR-263031
AKT1	PIKFYVE	Ser307 View in OncoXplorer	PARNRSAsITNLSLD	phosphorylation up-regulates	15546921	SIGNOR-252474
AKT	PIKFYVE	Ser307 View in OncoXplorer	PARNRSAsITNLSLD	phosphorylation up-regulates	15546921	SIGNOR-130920

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
SGK3	phosphorylation up-regulates →	PIKFYVE PSer318	phosphorylation up-regulates →	PIKFYVE	22470488	SIGNOR-279113
AMPK	phosphorylation up-regulates →	PIKFYVE PSer307	phosphorylation up-regulates →	PIKFYVE	23905686	SIGNOR-263031
AKT1	phosphorylation up-regulates →	PIKFYVE PSer307	phosphorylation up-regulates →	PIKFYVE	15546921	SIGNOR-252474
AKT	phosphorylation up-regulates →	PIKFYVE PSer307	phosphorylation up-regulates →	PIKFYVE	15546921	SIGNOR-130920

Regulator	Mechanism/Effect	Target	SIGNOR-ID
SGK3	phosphorylation → up-regulates activity	PIKFYVE	SIGNOR-279113
AMPK	phosphorylation → up-regulates activity	PIKFYVE	SIGNOR-263031
AKT1	phosphorylation → up-regulates	PIKFYVE	SIGNOR-252474
AKT	phosphorylation → up-regulates	PIKFYVE	SIGNOR-130920