| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | PIKFYVE | Ser307 | PARNRSAsITNLSLD | phosphorylation up-regulates activity | 23905686 | SIGNOR-263031 |
| AKT1 | PIKFYVE | Ser307 | PARNRSAsITNLSLD | phosphorylation up-regulates | 15546921 | SIGNOR-252474 |
| AKT | PIKFYVE | Ser307 | PARNRSAsITNLSLD | phosphorylation up-regulates | 15546921 | SIGNOR-130920 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AMPK | phosphorylation up-regulates → | PIKFYVE PSer307 | phosphorylation up-regulates → | PIKFYVE | 23905686 | SIGNOR-263031 |
| AKT1 | phosphorylation up-regulates → | PIKFYVE PSer307 | phosphorylation up-regulates → | PIKFYVE | 15546921 | SIGNOR-252474 |
| AKT | phosphorylation up-regulates → | PIKFYVE PSer307 | phosphorylation up-regulates → | PIKFYVE | 15546921 | SIGNOR-130920 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AMPK | phosphorylation → up-regulates activity | PIKFYVE | SIGNOR-263031 |
| AKT1 | phosphorylation → up-regulates | PIKFYVE | SIGNOR-252474 |
| AKT | phosphorylation → up-regulates | PIKFYVE | SIGNOR-130920 |
