Entity Details

Name AMOTL2
ID Q9Y2J4
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
LATS2AMOTL2Ser159HGHVRSLsERLLQLSphosphorylation
down-regulates activity		24225952SIGNOR-272084
MTORAMOTL2Ser759
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SSSQRAAsLDSVATSphosphorylation
down-regulates activity		25998128SIGNOR-272086
FGFR1AMOTL2Tyr107KGEELPTyEEAKAHSphosphorylation
up-regulates activity		21937427SIGNOR-271869
mTORC2AMOTL2Ser759
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SSSQRAAsLDSVATSphosphorylation
down-regulates activity		25998128SIGNOR-272085
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
LATS2phosphorylation
up-regulates
→
AMOTL2
PSer159		phosphorylation
down-regulates
⊣		AMOTL224225952SIGNOR-272084
MTORphosphorylation
up-regulates
→
AMOTL2
PSer759		phosphorylation
down-regulates
⊣		AMOTL225998128SIGNOR-272086
FGFR1phosphorylation
up-regulates
→
AMOTL2
PTyr107		phosphorylation
up-regulates
→		AMOTL221937427SIGNOR-271869
mTORC2phosphorylation
up-regulates
→
AMOTL2
PSer759		phosphorylation
down-regulates
⊣		AMOTL225998128SIGNOR-272085
Regulator Mechanism/Effect Target SIGNOR-ID
LATS2phosphorylation
→
down-regulates activity 		AMOTL2SIGNOR-272084
MTORphosphorylation
→
down-regulates activity 		AMOTL2SIGNOR-272086
FGFR1phosphorylation
→
up-regulates activity 		AMOTL2SIGNOR-271869
mTORC2phosphorylation
→
down-regulates activity 		AMOTL2SIGNOR-272085