Entity Details

Name SIK3
ID Q9Y2K2
Role kinase
Enzymatic Domains
Protein kinase 66-317
PROSITE-ProRule
UBA 344-384
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
SIK3PER2–phosphorylation
down-regulates quantity by destabilization		29227248SIGNOR-279570
SIK3HDAC4–phosphorylation
down-regulates activity		21565608SIGNOR-279430
SIK3CRTC2Ser171SALNRTSsDSALHTSphosphorylation
down-regulates activity		16306228SIGNOR-249172
SIK3CRTC2Ser348PSLQSSLsNPNLQASphosphorylation
down-regulates activity		16306228SIGNOR-249170
SIK3CRTC2Ser70RSSHYGGsLPNVNQIphosphorylation
down-regulates activity		16306228SIGNOR-249171
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
SIK3phosphorylation
up-regulates
→
CRTC2
PSer171		phosphorylation
down-regulates
⊣		CRTC216306228SIGNOR-249172
SIK3phosphorylation
up-regulates
→
CRTC2
PSer348		phosphorylation
down-regulates
⊣		CRTC216306228SIGNOR-249170
SIK3phosphorylation
up-regulates
→
CRTC2
PSer70		phosphorylation
down-regulates
⊣		CRTC216306228SIGNOR-249171
Regulator Mechanism/Effect Target SIGNOR-ID
SIK3phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		PER2SIGNOR-279570
SIK3phosphorylation
→
down-regulates activity 		HDAC4SIGNOR-279430
SIK3phosphorylation
→
down-regulates activity 		CRTC2SIGNOR-249172
SIK3phosphorylation
→
down-regulates activity 		CRTC2SIGNOR-249170
SIK3phosphorylation
→
down-regulates activity 		CRTC2SIGNOR-249171