| Name | PTPN22 |
| ID | Q9Y2R2 |
| Role | phosphatase |
| Enzymatic Domains |
Tyrosine-protein phosphatase 24-289 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN22 | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates | 16461343 | SIGNOR-144341 |
| PTPN22 | LCK | Tyr394 | RLIEDNEyTAREGAK | dephosphorylation down-regulates activity | 16461343 | SIGNOR-248836 |
| PTPN22 | CD247 | – | dephosphorylation down-regulates | 16461343 | SIGNOR-144337 | |
| PTPN22 | CD247 | – | dephosphorylation down-regulates activity | 16461343 | SIGNOR-248837 | |
| PTPN22 | CBL | Ser798 | SDISNASsSFGWLSL | dephosphorylation down-regulates | 10068674 | SIGNOR-65405 |
| PTPN22 | ZAP70 | Tyr493 | LGADDSYyTARSAGK | dephosphorylation down-regulates | 16461343 | SIGNOR-144345 |
| PTPN22 | ZAP70 | Tyr493 | LGADDSYyTARSAGK | dephosphorylation down-regulates activity | 16461343 | SIGNOR-248838 |
| PTPN22 | NLRP3 | – | dephosphorylation up-regulates activity | 28786745 | SIGNOR-277056 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN22 | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 16461343 | SIGNOR-144341 |
| PTPN22 | dephosphorylation down-regulates ⊣ | LCK PTyr394 | dephosphorylation up-regulates → | LCK | 16461343 | SIGNOR-248836 |
| PTPN22 | dephosphorylation down-regulates ⊣ | CBL PSer798 | dephosphorylation up-regulates → | CBL | 10068674 | SIGNOR-65405 |
| PTPN22 | dephosphorylation down-regulates ⊣ | ZAP70 PTyr493 | dephosphorylation up-regulates → | ZAP70 | 16461343 | SIGNOR-144345 |
| PTPN22 | dephosphorylation down-regulates ⊣ | ZAP70 PTyr493 | dephosphorylation up-regulates → | ZAP70 | 16461343 | SIGNOR-248838 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN22 | dephosphorylation down-regulates | LCK | SIGNOR-144341 |
| PTPN22 | dephosphorylation → down-regulates activity | LCK | SIGNOR-248836 |
| PTPN22 | dephosphorylation down-regulates | CD247 | SIGNOR-144337 |
| PTPN22 | dephosphorylation → down-regulates activity | CD247 | SIGNOR-248837 |
| PTPN22 | dephosphorylation down-regulates | CBL | SIGNOR-65405 |
| PTPN22 | dephosphorylation down-regulates | ZAP70 | SIGNOR-144345 |
| PTPN22 | dephosphorylation → down-regulates activity | ZAP70 | SIGNOR-248838 |
| PTPN22 | dephosphorylation → up-regulates activity | NLRP3 | SIGNOR-277056 |