Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
DYRK1B	GYS1	Ser641	YRYPRPAsVPPSPSL	phosphorylation down-regulates activity	14593110	SIGNOR-260633
DYRK1B	HNF1A	Ser249	IQRGVSPsQAQGLGS	phosphorylation up-regulates	11980910	SIGNOR-86728
DYRK1B	CCND1	Thr288	VDLACTPtDVRDVDI	phosphorylation down-regulates	15546868	SIGNOR-235801
DYRK1B	CCND1	Thr288	VDLACTPtDVRDVDI	phosphorylation down-regulates	17046823	SIGNOR-150126
DYRK1B	CDKN1A	Ser153	SMTDFYHsKRRLIFS	phosphorylation up-regulates activity	15851482	SIGNOR-235635
DYRK1B	CDKN1B	Ser10	NVRVSNGsPSLERMD	phosphorylation up-regulates	15546868	SIGNOR-235805
DYRK1B	ID2	Thr27	LGISRSKtPVDDPMS	phosphorylation down-regulates activity	26735018	SIGNOR-279033
DYRK1B	NKX3-1	Ser185	KTKRKQLsSELGDLE	phosphorylation down-regulates quantity by destabilization	25777618	SIGNOR-279610
DYRK1B	HDAC9	Ser240	KVAERRSsPLLRRKD	phosphorylation down-regulates	15546868	SIGNOR-235813
DYRK1B	HDAC5	Ser279	KVAERRSsPLLRRKD	phosphorylation down-regulates activity	15546868	SIGNOR-235809
DYRK1B	DYRK1B	Tyr271	CQLGQRIyQYIQSRF	phosphorylation up-regulates	10910078	SIGNOR-79806
DYRK1B	DYRK1B	Tyr273	LGQRIYQyIQSRFYR	phosphorylation up-regulates	10910078	SIGNOR-79810

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
DYRK1B	phosphorylation up-regulates →	GYS1 PSer641	phosphorylation down-regulates ⊣	GYS1	14593110	SIGNOR-260633
DYRK1B	phosphorylation up-regulates →	HNF1A PSer249	phosphorylation up-regulates →	HNF1A	11980910	SIGNOR-86728
DYRK1B	phosphorylation up-regulates →	CCND1 PThr288	phosphorylation down-regulates ⊣	CCND1	15546868	SIGNOR-235801
DYRK1B	phosphorylation up-regulates →	CCND1 PThr288	phosphorylation down-regulates ⊣	CCND1	17046823	SIGNOR-150126
DYRK1B	phosphorylation up-regulates →	CDKN1A PSer153	phosphorylation up-regulates →	CDKN1A	15851482	SIGNOR-235635
DYRK1B	phosphorylation up-regulates →	CDKN1B PSer10	phosphorylation up-regulates →	CDKN1B	15546868	SIGNOR-235805
DYRK1B	phosphorylation up-regulates →	ID2 PThr27	phosphorylation down-regulates ⊣	ID2	26735018	SIGNOR-279033
DYRK1B	phosphorylation up-regulates →	NKX3-1 PSer185	phosphorylation down-regulates ⊣	NKX3-1	25777618	SIGNOR-279610
DYRK1B	phosphorylation up-regulates →	HDAC9 PSer240	phosphorylation down-regulates ⊣	HDAC9	15546868	SIGNOR-235813
DYRK1B	phosphorylation up-regulates →	HDAC5 PSer279	phosphorylation down-regulates ⊣	HDAC5	15546868	SIGNOR-235809
DYRK1B	phosphorylation up-regulates →	DYRK1B PTyr271	phosphorylation up-regulates →	DYRK1B	10910078	SIGNOR-79806
DYRK1B	phosphorylation up-regulates →	DYRK1B PTyr273	phosphorylation up-regulates →	DYRK1B	10910078	SIGNOR-79810

Regulator	Mechanism/Effect	Target	SIGNOR-ID
DYRK1B	phosphorylation → down-regulates activity	GYS1	SIGNOR-260633
DYRK1B	phosphorylation → up-regulates	HNF1A	SIGNOR-86728
DYRK1B	phosphorylation down-regulates	CCND1	SIGNOR-235801
DYRK1B	phosphorylation down-regulates	CCND1	SIGNOR-150126
DYRK1B	phosphorylation → up-regulates activity	CDKN1A	SIGNOR-235635
DYRK1B	phosphorylation → up-regulates	CDKN1B	SIGNOR-235805
DYRK1B	phosphorylation → down-regulates activity	ID2	SIGNOR-279033
DYRK1B	phosphorylation down-regulates quantity by destabilization	NKX3-1	SIGNOR-279610
DYRK1B	phosphorylation down-regulates	HDAC9	SIGNOR-235813
DYRK1B	phosphorylation → down-regulates activity	HDAC5	SIGNOR-235809
DYRK1B	phosphorylation → up-regulates	DYRK1B	SIGNOR-79806
DYRK1B	phosphorylation → up-regulates	DYRK1B	SIGNOR-79810