| Name | RAPGEF2 |
| ID | Q9Y4G8 |
| Role | substrate |
| Enzymatic Domains |
N-terminal Ras-GEF 267-380 PROSITE-ProRule
PDZ 385-470 PROSITE-ProRule| Warning: Undefined array key "source" in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 17 Warning: Undefined array key "source" in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 20 Warning: Undefined array key "source" in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 23 Warning: Undefined array key "source" in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 26
Ras-associating 606-692 PROSITE-ProRule
Ras-GEF 717-944 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCQ | RAPGEF2 | Ser960 | KKRVRRSsFLNAKKL | phosphorylation up-regulates | 18796635 | SIGNOR-181186 |
| CDK5 | RAPGEF2 | Ser1124 | PPTSPQSsPRKGYTL | phosphorylation up-regulates activity | 25189171 | SIGNOR-278258 |
| IKBKB | RAPGEF2 | – | phosphorylation down-regulates quantity by destabilization | 24290981 | SIGNOR-279805 | |
| IKBKB | RAPGEF2 | – | phosphorylation down-regulates quantity by destabilization | 24290981 | SIGNOR-279807 | |
| CSNK1A1 | RAPGEF2 | Ser1248 | AADSGRGsWTSCSSG | phosphorylation down-regulates quantity by destabilization | 24290981 | SIGNOR-276604 |
| CSNK1A1 | RAPGEF2 | Ser1244 | ASLDAADsGRGSWTS | phosphorylation down-regulates quantity by destabilization | 24290981 | SIGNOR-276605 |
| PLK2 | RAPGEF2 | – | phosphorylation up-regulates activity | 21382555 | SIGNOR-280066 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCQ | phosphorylation up-regulates → | RAPGEF2 PSer960 | phosphorylation up-regulates → | RAPGEF2 | 18796635 | SIGNOR-181186 |
| CDK5 | phosphorylation up-regulates → | RAPGEF2 PSer1124 | phosphorylation up-regulates → | RAPGEF2 | 25189171 | SIGNOR-278258 |
| CSNK1A1 | phosphorylation up-regulates → | RAPGEF2 PSer1248 | phosphorylation down-regulates ⊣ | RAPGEF2 | 24290981 | SIGNOR-276604 |
| CSNK1A1 | phosphorylation up-regulates → | RAPGEF2 PSer1244 | phosphorylation down-regulates ⊣ | RAPGEF2 | 24290981 | SIGNOR-276605 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCQ | phosphorylation → up-regulates | RAPGEF2 | SIGNOR-181186 |
| CDK5 | phosphorylation → up-regulates activity | RAPGEF2 | SIGNOR-278258 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | RAPGEF2 | SIGNOR-279805 |
| IKBKB | phosphorylation down-regulates quantity by destabilization | RAPGEF2 | SIGNOR-279807 |
| CSNK1A1 | phosphorylation down-regulates quantity by destabilization | RAPGEF2 | SIGNOR-276604 |
| CSNK1A1 | phosphorylation down-regulates quantity by destabilization | RAPGEF2 | SIGNOR-276605 |
| PLK2 | phosphorylation → up-regulates activity | RAPGEF2 | SIGNOR-280066 |