Entity Details

Name TRAF6
ID Q9Y4K3
Role substrate
Enzymatic Domains
MATH 350-499
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
SRCTRAF6Tyr288SVIPDSGyISEVRNFphosphorylation
up-regulates activity		37977223SIGNOR-277865
SRCTRAF6Tyr473RNPKGFGyVTFMHLEphosphorylation
up-regulates activity		37977223SIGNOR-277867
SRCTRAF6Tyr68DPPLESKyECPICLMphosphorylation
up-regulates activity		37977223SIGNOR-277862
RPS6KA3TRAF6Ser46TASTGNLsSSFMEEIphosphorylation
up-regulates activity		29563609SIGNOR-278302
SRCTRAF6Tyr326KMETQSMyVSELKRTphosphorylation
up-regulates activity		37977223SIGNOR-277863
SRCTRAF6Tyr353AQQCNGIyIWKIGNFphosphorylation
up-regulates activity		37977223SIGNOR-277864
SRCTRAF6Tyr381VIHSPGFyTGKPGYKphosphorylation
up-regulates activity		37977223SIGNOR-277866
GSK3BTRAF6Thr266ARHLQENtQSHMRMLphosphorylation
down-regulates quantity by destabilization		30806153SIGNOR-277438
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
SRCphosphorylation
up-regulates
→
TRAF6
PTyr288		phosphorylation
up-regulates
→		TRAF637977223SIGNOR-277865
SRCphosphorylation
up-regulates
→
TRAF6
PTyr473		phosphorylation
up-regulates
→		TRAF637977223SIGNOR-277867
SRCphosphorylation
up-regulates
→
TRAF6
PTyr68		phosphorylation
up-regulates
→		TRAF637977223SIGNOR-277862
RPS6KA3phosphorylation
up-regulates
→
TRAF6
PSer46		phosphorylation
up-regulates
→		TRAF629563609SIGNOR-278302
SRCphosphorylation
up-regulates
→
TRAF6
PTyr326		phosphorylation
up-regulates
→		TRAF637977223SIGNOR-277863
SRCphosphorylation
up-regulates
→
TRAF6
PTyr353		phosphorylation
up-regulates
→		TRAF637977223SIGNOR-277864
SRCphosphorylation
up-regulates
→
TRAF6
PTyr381		phosphorylation
up-regulates
→		TRAF637977223SIGNOR-277866
GSK3Bphosphorylation
up-regulates
→
TRAF6
PThr266		phosphorylation
down-regulates
⊣		TRAF630806153SIGNOR-277438
Regulator Mechanism/Effect Target SIGNOR-ID
SRCphosphorylation
→
up-regulates activity 		TRAF6SIGNOR-277865
SRCphosphorylation
→
up-regulates activity 		TRAF6SIGNOR-277867
SRCphosphorylation
→
up-regulates activity 		TRAF6SIGNOR-277862
RPS6KA3phosphorylation
→
up-regulates activity 		TRAF6SIGNOR-278302
SRCphosphorylation
→
up-regulates activity 		TRAF6SIGNOR-277863
SRCphosphorylation
→
up-regulates activity 		TRAF6SIGNOR-277864
SRCphosphorylation
→
up-regulates activity 		TRAF6SIGNOR-277866
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		TRAF6SIGNOR-277438