| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ULK1 | ATG4B | Ser316 | SIAELDPsIAVGFFC | phosphorylation down-regulates activity | 28821708 | SIGNOR-279434 |
| STK26 | ATG4B | Ser383 | RLERFFDsEDEDFEI | phosphorylation up-regulates activity | 29232556 | SIGNOR-278254 |
| STK26 | ATG4B | Ser383 | RLERFFDsEDEDFEI | phosphorylation up-regulates activity | 29232556 | SIGNOR-275833 |
| AKT | ATG4B | Ser34 | WILGRKYsIFTEKDE | phosphorylation up-regulates activity | 29165041 | SIGNOR-275836 |
| PFKP | ATG4B | Ser34 | WILGRKYsIFTEKDE | phosphorylation up-regulates activity | 33607258 | SIGNOR-275832 |
| AKT1 | ATG4B | Ser34 | WILGRKYsIFTEKDE | phosphorylation up-regulates activity | 29165041 | SIGNOR-275834 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ULK1 | phosphorylation up-regulates → | ATG4B PSer316 | phosphorylation down-regulates ⊣ | ATG4B | 28821708 | SIGNOR-279434 |
| STK26 | phosphorylation up-regulates → | ATG4B PSer383 | phosphorylation up-regulates → | ATG4B | 29232556 | SIGNOR-278254 |
| STK26 | phosphorylation up-regulates → | ATG4B PSer383 | phosphorylation up-regulates → | ATG4B | 29232556 | SIGNOR-275833 |
| AKT | phosphorylation up-regulates → | ATG4B PSer34 | phosphorylation up-regulates → | ATG4B | 29165041 | SIGNOR-275836 |
| PFKP | phosphorylation up-regulates → | ATG4B PSer34 | phosphorylation up-regulates → | ATG4B | 33607258 | SIGNOR-275832 |
| AKT1 | phosphorylation up-regulates → | ATG4B PSer34 | phosphorylation up-regulates → | ATG4B | 29165041 | SIGNOR-275834 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ULK1 | phosphorylation → down-regulates activity | ATG4B | SIGNOR-279434 |
| STK26 | phosphorylation → up-regulates activity | ATG4B | SIGNOR-278254 |
| STK26 | phosphorylation → up-regulates activity | ATG4B | SIGNOR-275833 |
| AKT | phosphorylation → up-regulates activity | ATG4B | SIGNOR-275836 |
| PFKP | phosphorylation → up-regulates activity | ATG4B | SIGNOR-275832 |
| AKT1 | phosphorylation → up-regulates activity | ATG4B | SIGNOR-275834 |