| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | USP16 | Ser386 | HESFLDLsLPVLDDQ | phosphorylation up-regulates activity | 26323689 | SIGNOR-274015 |
| TTK | USP16 | Ser415 | VEDEDQDsEEEKDND | phosphorylation down-regulates quantity by destabilization | 28380042 | SIGNOR-277350 |
| CDK1 | USP16 | Ser552 | DLEVLTSsPTRNLNG | phosphorylation up-regulates | 24013421 | SIGNOR-202678 |
| TTK | USP16 | Thr554 | EVLTSSPtRNLNGAY | phosphorylation down-regulates quantity by destabilization | 28380042 | SIGNOR-277351 |
| PLK1 | USP16 | Ser330 | ILKAFGNsTEKLDEE | phosphorylation up-regulates activity | 26323689 | SIGNOR-274016 |
| PLK1 | USP16 | Ser486 | SEYEAEMsLQGEVNI | phosphorylation up-regulates activity | 26323689 | SIGNOR-274017 |
| PLK1 | USP16 | Ser486 | SEYEAEMsLQGEVNI | phosphorylation up-regulates activity | 26323689 | SIGNOR-278270 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | USP16 PSer386 | phosphorylation up-regulates → | USP16 | 26323689 | SIGNOR-274015 |
| TTK | phosphorylation up-regulates → | USP16 PSer415 | phosphorylation down-regulates ⊣ | USP16 | 28380042 | SIGNOR-277350 |
| CDK1 | phosphorylation up-regulates → | USP16 PSer552 | phosphorylation up-regulates → | USP16 | 24013421 | SIGNOR-202678 |
| TTK | phosphorylation up-regulates → | USP16 PThr554 | phosphorylation down-regulates ⊣ | USP16 | 28380042 | SIGNOR-277351 |
| PLK1 | phosphorylation up-regulates → | USP16 PSer330 | phosphorylation up-regulates → | USP16 | 26323689 | SIGNOR-274016 |
| PLK1 | phosphorylation up-regulates → | USP16 PSer486 | phosphorylation up-regulates → | USP16 | 26323689 | SIGNOR-274017 |
| PLK1 | phosphorylation up-regulates → | USP16 PSer486 | phosphorylation up-regulates → | USP16 | 26323689 | SIGNOR-278270 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → up-regulates activity | USP16 | SIGNOR-274015 |
| TTK | phosphorylation down-regulates quantity by destabilization | USP16 | SIGNOR-277350 |
| CDK1 | phosphorylation → up-regulates | USP16 | SIGNOR-202678 |
| TTK | phosphorylation down-regulates quantity by destabilization | USP16 | SIGNOR-277351 |
| PLK1 | phosphorylation → up-regulates activity | USP16 | SIGNOR-274016 |
| PLK1 | phosphorylation → up-regulates activity | USP16 | SIGNOR-274017 |
| PLK1 | phosphorylation → up-regulates activity | USP16 | SIGNOR-278270 |
