| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | TACC3 | Ser558 | ESALRKQsLYLKFDP | phosphorylation up-regulates activity | 17545617 | SIGNOR-262655 |
| AURKA | TACC3 | Ser34 | PEVTGRSsVLRVSQK | phosphorylation unknown | 26134678 | SIGNOR-263697 |
| AURKA | TACC3 | Ser552 | GTSSFKEsALRKQSL | phosphorylation unknown | 26134678 | SIGNOR-263698 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | phosphorylation up-regulates → | TACC3 PSer558 | phosphorylation up-regulates → | TACC3 | 17545617 | SIGNOR-262655 |
| AURKA | phosphorylation up-regulates → | TACC3 PSer34 | phosphorylation down-regulates ⊣ | TACC3 | 26134678 | SIGNOR-263697 |
| AURKA | phosphorylation up-regulates → | TACC3 PSer552 | phosphorylation down-regulates ⊣ | TACC3 | 26134678 | SIGNOR-263698 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKA | phosphorylation → up-regulates activity | TACC3 | SIGNOR-262655 |
| AURKA | phosphorylation → unknown | TACC3 | SIGNOR-263697 |
| AURKA | phosphorylation → unknown | TACC3 | SIGNOR-263698 |
