| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TTK | MAD1L1 | – | phosphorylation up-regulates activity | 18541701 | SIGNOR-279000 | |
| ATM | MAD1L1 | Ser214 | KIQELQAsQEARADH | phosphorylation up-regulates activity | 24728176 | SIGNOR-278467 |
| PLK1 | MAD1L1 | Thr680 | SKMQLLEtEFSHTVG | phosphorylation up-regulates activity | 18922800 | SIGNOR-276173 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | MAD1L1 PSer214 | phosphorylation up-regulates → | MAD1L1 | 24728176 | SIGNOR-278467 |
| PLK1 | phosphorylation up-regulates → | MAD1L1 PThr680 | phosphorylation up-regulates → | MAD1L1 | 18922800 | SIGNOR-276173 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TTK | phosphorylation → up-regulates activity | MAD1L1 | SIGNOR-279000 |
| ATM | phosphorylation → up-regulates activity | MAD1L1 | SIGNOR-278467 |
| PLK1 | phosphorylation → up-regulates activity | MAD1L1 | SIGNOR-276173 |