| Name | NCOA3 |
| ID | Q9Y6Q9 |
| Role | substrate |
| Enzymatic Domains |
bHLH 25-82 PROSITE-ProRule
PAS 110-180 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | NCOA3 | Ser509 | GVHSPMAsSGNTGNH | phosphorylation down-regulates quantity by destabilization | 17574025 | SIGNOR-276067 |
| PFKFB4 | NCOA3 | Ser857 | PPYNRAVsLDSPVSV | phosphorylation up-regulates activity | 29615789 | SIGNOR-267269 |
| ABL1 | NCOA3 | Tyr1357 | HPQAASIyQSSEMKG | phosphorylation up-regulates | 18765637 | SIGNOR-180571 |
| CyclinB/CDK1 | NCOA3 | Ser728 | VVKQEQLsPKKKENN | phosphorylation down-regulates | 22163316 | SIGNOR-216892 |
| MAPK14 | NCOA3 | Ser505 | SPVAGVHsPMASSGN | phosphorylation up-regulates activity | 15383283 | SIGNOR-250103 |
| PRKACA | NCOA3 | Ser857 | PPYNRAVsLDSPVSV | phosphorylation up-regulates | 22505454 | SIGNOR-196961 |
| DYRK3 | NCOA3 | Ser1330 | PAFGRVSsPPNAMMS | phosphorylation down-regulates activity | 31066068 | SIGNOR-275451 |
| CSNK1D | NCOA3 | Ser601 | SDKESKEsSVEGAEN | phosphorylation up-regulates | 19339517 | SIGNOR-184946 |
| CDK1 | NCOA3 | Ser728 | VVKQEQLsPKKKENN | phosphorylation down-regulates | 22163316 | SIGNOR-195233 |
| MAPK14 | NCOA3 | Ser860 | NRAVSLDsPVSVGSS | phosphorylation up-regulates activity | 15383283 | SIGNOR-250105 |
| PRKACA | NCOA3 | Ser857 | PPYNRAVsLDSPVSV | phosphorylation up-regulates | 15383283 | SIGNOR-129349 |
| MAPK6 | NCOA3 | Ser857 | PPYNRAVsLDSPVSV | phosphorylation up-regulates | 22505454 | SIGNOR-196957 |
| CHUK | NCOA3 | Ser857 | PPYNRAVsLDSPVSV | phosphorylation up-regulates | 22505454 | SIGNOR-196953 |
| IKBKB | NCOA3 | – | phosphorylation up-regulates activity | 11971985 | SIGNOR-251298 | |
| CHUK | NCOA3 | Ser857 | PPYNRAVsLDSPVSV | phosphorylation up-regulates | 15383283 | SIGNOR-127064 |
| CHKA | NCOA3 | – | phosphorylation down-regulates quantity by destabilization | 21577200 | SIGNOR-280229 | |
| CHUK | NCOA3 | – | phosphorylation up-regulates | 15808510 | SIGNOR-135050 | |
| MAPK14 | NCOA3 | Ser543 | SLLSTLSsPGPKLDN | phosphorylation up-regulates activity | 15383283 | SIGNOR-250104 |
| MAPK14 | NCOA3 | Ser867 | SPVSVGSsPPVKNIS | phosphorylation up-regulates activity | 15383283 | SIGNOR-250106 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3A | phosphorylation up-regulates → | NCOA3 PSer509 | phosphorylation down-regulates ⊣ | NCOA3 | 17574025 | SIGNOR-276067 |
| PFKFB4 | phosphorylation up-regulates → | NCOA3 PSer857 | phosphorylation up-regulates → | NCOA3 | 29615789 | SIGNOR-267269 |
| ABL1 | phosphorylation up-regulates → | NCOA3 PTyr1357 | phosphorylation up-regulates → | NCOA3 | 18765637 | SIGNOR-180571 |
| CyclinB/CDK1 | phosphorylation up-regulates → | NCOA3 PSer728 | phosphorylation down-regulates ⊣ | NCOA3 | 22163316 | SIGNOR-216892 |
| MAPK14 | phosphorylation up-regulates → | NCOA3 PSer505 | phosphorylation up-regulates → | NCOA3 | 15383283 | SIGNOR-250103 |
| PRKACA | phosphorylation up-regulates → | NCOA3 PSer857 | phosphorylation up-regulates → | NCOA3 | 22505454 | SIGNOR-196961 |
| DYRK3 | phosphorylation up-regulates → | NCOA3 PSer1330 | phosphorylation down-regulates ⊣ | NCOA3 | 31066068 | SIGNOR-275451 |
| CSNK1D | phosphorylation up-regulates → | NCOA3 PSer601 | phosphorylation up-regulates → | NCOA3 | 19339517 | SIGNOR-184946 |
| CDK1 | phosphorylation up-regulates → | NCOA3 PSer728 | phosphorylation down-regulates ⊣ | NCOA3 | 22163316 | SIGNOR-195233 |
| MAPK14 | phosphorylation up-regulates → | NCOA3 PSer860 | phosphorylation up-regulates → | NCOA3 | 15383283 | SIGNOR-250105 |
| PRKACA | phosphorylation up-regulates → | NCOA3 PSer857 | phosphorylation up-regulates → | NCOA3 | 15383283 | SIGNOR-129349 |
| MAPK6 | phosphorylation up-regulates → | NCOA3 PSer857 | phosphorylation up-regulates → | NCOA3 | 22505454 | SIGNOR-196957 |
| CHUK | phosphorylation up-regulates → | NCOA3 PSer857 | phosphorylation up-regulates → | NCOA3 | 22505454 | SIGNOR-196953 |
| CHUK | phosphorylation up-regulates → | NCOA3 PSer857 | phosphorylation up-regulates → | NCOA3 | 15383283 | SIGNOR-127064 |
| MAPK14 | phosphorylation up-regulates → | NCOA3 PSer543 | phosphorylation up-regulates → | NCOA3 | 15383283 | SIGNOR-250104 |
| MAPK14 | phosphorylation up-regulates → | NCOA3 PSer867 | phosphorylation up-regulates → | NCOA3 | 15383283 | SIGNOR-250106 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3A | phosphorylation down-regulates quantity by destabilization | NCOA3 | SIGNOR-276067 |
| PFKFB4 | phosphorylation → up-regulates activity | NCOA3 | SIGNOR-267269 |
| ABL1 | phosphorylation → up-regulates | NCOA3 | SIGNOR-180571 |
| CyclinB/CDK1 | phosphorylation down-regulates | NCOA3 | SIGNOR-216892 |
| MAPK14 | phosphorylation → up-regulates activity | NCOA3 | SIGNOR-250103 |
| PRKACA | phosphorylation → up-regulates | NCOA3 | SIGNOR-196961 |
| DYRK3 | phosphorylation → down-regulates activity | NCOA3 | SIGNOR-275451 |
| CSNK1D | phosphorylation → up-regulates | NCOA3 | SIGNOR-184946 |
| CDK1 | phosphorylation down-regulates | NCOA3 | SIGNOR-195233 |
| MAPK14 | phosphorylation → up-regulates activity | NCOA3 | SIGNOR-250105 |
| PRKACA | phosphorylation → up-regulates | NCOA3 | SIGNOR-129349 |
| MAPK6 | phosphorylation → up-regulates | NCOA3 | SIGNOR-196957 |
| CHUK | phosphorylation → up-regulates | NCOA3 | SIGNOR-196953 |
| IKBKB | phosphorylation → up-regulates activity | NCOA3 | SIGNOR-251298 |
| CHUK | phosphorylation → up-regulates | NCOA3 | SIGNOR-127064 |
| CHKA | phosphorylation down-regulates quantity by destabilization | NCOA3 | SIGNOR-280229 |
| CHUK | phosphorylation → up-regulates | NCOA3 | SIGNOR-135050 |
| MAPK14 | phosphorylation → up-regulates activity | NCOA3 | SIGNOR-250104 |
| MAPK14 | phosphorylation → up-regulates activity | NCOA3 | SIGNOR-250106 |