Entity Details

Name TSC
ID SIGNOR-C101
Role substrate
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AKT1TSC–phosphorylation
down-regulates activity		19593385SIGNOR-235340
AMPKTSC–phosphorylation
up-regulates activity		16959574SIGNOR-217749
RPS6KA1TSC–phosphorylation
down-regulates activity		15342917SIGNOR-217900
RPS6KTSC–phosphorylation
down-regulates activity		15342917SIGNOR-256311
AKTTSC–phosphorylation
down-regulates activity		19593385SIGNOR-251526
AKT1TSC–phosphorylation
down-regulates activity		12150915SIGNOR-235628
AKT2TSC–phosphorylation
down-regulates activity		19593385SIGNOR-235852
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
Regulator Mechanism/Effect Target SIGNOR-ID
AKT1phosphorylation
→
down-regulates activity 		TSCSIGNOR-235340
AMPKphosphorylation
→
up-regulates activity 		TSCSIGNOR-217749
RPS6KA1phosphorylation
→
down-regulates activity 		TSCSIGNOR-217900
RPS6Kphosphorylation
→
down-regulates activity 		TSCSIGNOR-256311
AKTphosphorylation
→
down-regulates activity 		TSCSIGNOR-251526
AKT1phosphorylation
→
down-regulates activity 		TSCSIGNOR-235628
AKT2phosphorylation
→
down-regulates activity 		TSCSIGNOR-235852