| Name | GSK3B/Axin/APC |
| ID | SIGNOR-C110 |
| Role | kinase |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B/Axin/APC | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 16341017 | SIGNOR-228014 |
| GSK3B/Axin/APC | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 11955436 | SIGNOR-227897 |
| GSK3B/Axin/APC | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 11955436 | SIGNOR-227901 |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 11955436 | SIGNOR-260015 |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 11955436 | SIGNOR-227905 |
| GSK3B/Axin/APC | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 16293724 | SIGNOR-227885 |
| GSK3B/Axin/APC | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 16293724 | SIGNOR-227889 |
| GSK3B/Axin/APC | CTNNB1 | – | phosphorylation down-regulates activity | 16293724 | SIGNOR-227893 | |
| GSK3B/Axin/APC | CTNNB1 | Ser33 | QQQSYLDsGIHSGAT | phosphorylation down-regulates activity | 19303846 | SIGNOR-227870 |
| GSK3B/Axin/APC | CTNNB1 | Ser37 | YLDSGIHsGATTTAP | phosphorylation down-regulates activity | 19303846 | SIGNOR-227874 |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 19303846 | SIGNOR-227878 |
| GSK3B/Axin/APC | CTNNB1 | Thr41 | GIHSGATtTAPSLSG | phosphorylation down-regulates activity | 23151663 | SIGNOR-227866 |
| GSK3B/Axin/APC | PSEN1 | Ser353 | SHLGPHRsTPESRAA | phosphorylation down-regulates activity | 17360711 | SIGNOR-228018 |
| GSK3B/Axin/APC | PSEN1 | Ser357 | PHRSTPEsRAAVQEL | phosphorylation down-regulates activity | 17360711 | SIGNOR-228022 |
| GSK3B/Axin/APC | ROR2 | Ser864 | PKPSSHHsGSGSTST | phosphorylation down-regulates activity | 21078818 | SIGNOR-228026 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B/Axin/APC | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 16341017 | SIGNOR-228014 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-227897 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-227901 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-260015 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 11955436 | SIGNOR-227905 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-227885 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 16293724 | SIGNOR-227889 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer33 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-227870 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PSer37 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-227874 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 19303846 | SIGNOR-227878 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | CTNNB1 PThr41 | phosphorylation down-regulates ⊣ | CTNNB1 | 23151663 | SIGNOR-227866 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | PSEN1 PSer353 | phosphorylation down-regulates ⊣ | PSEN1 | 17360711 | SIGNOR-228018 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | PSEN1 PSer357 | phosphorylation down-regulates ⊣ | PSEN1 | 17360711 | SIGNOR-228022 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | ROR2 PSer864 | phosphorylation down-regulates ⊣ | ROR2 | 21078818 | SIGNOR-228026 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B/Axin/APC | phosphorylation → up-regulates activity | LRP6 | SIGNOR-228014 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227897 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227901 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-260015 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227905 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227885 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227889 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227893 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227870 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227874 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227878 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | CTNNB1 | SIGNOR-227866 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | PSEN1 | SIGNOR-228018 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | PSEN1 | SIGNOR-228022 |
| GSK3B/Axin/APC | phosphorylation → down-regulates activity | ROR2 | SIGNOR-228026 |