Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAP4K5	GSK3B/Axin/APC	–		phosphorylation down-regulates activity	16914735	SIGNOR-228006
MAPK1	GSK3B/Axin/APC	–		phosphorylation down-regulates activity	28646232	SIGNOR-262521
PPM1A	GSK3B/Axin/APC	–		dephosphorylation down-regulates	10644691	SIGNOR-227955
ERK1/2	GSK3B/Axin/APC	–		phosphorylation down-regulates activity	28646232	SIGNOR-262519
Gbeta	GSK3B/Axin/APC	–		phosphorylation down-regulates activity	28646232	SIGNOR-270068
AKT	GSK3B/Axin/APC	–		phosphorylation down-regulates activity	16293724	SIGNOR-227952
CDC14B	GSK3B/Axin/APC	–		dephosphorylation up-regulates	18662541	SIGNOR-227927
CSNK1D	GSK3B/Axin/APC	–		phosphorylation up-regulates	12000790	SIGNOR-227970
MAPK3	GSK3B/Axin/APC	–		phosphorylation down-regulates activity	28646232	SIGNOR-262520
AURKA	GSK3B/Axin/APC	–		phosphorylation down-regulates activity	19060929	SIGNOR-227923
CSNK1E	GSK3B/Axin/APC	–		phosphorylation up-regulates	12000790	SIGNOR-227976

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAP4K5	phosphorylation → down-regulates activity	GSK3B/Axin/APC	SIGNOR-228006
MAPK1	phosphorylation → down-regulates activity	GSK3B/Axin/APC	SIGNOR-262521
PPM1A	dephosphorylation down-regulates	GSK3B/Axin/APC	SIGNOR-227955
ERK1/2	phosphorylation → down-regulates activity	GSK3B/Axin/APC	SIGNOR-262519
Gbeta	phosphorylation → down-regulates activity	GSK3B/Axin/APC	SIGNOR-270068
AKT	phosphorylation → down-regulates activity	GSK3B/Axin/APC	SIGNOR-227952
CDC14B	dephosphorylation → up-regulates	GSK3B/Axin/APC	SIGNOR-227927
CSNK1D	phosphorylation → up-regulates	GSK3B/Axin/APC	SIGNOR-227970
MAPK3	phosphorylation → down-regulates activity	GSK3B/Axin/APC	SIGNOR-262520
AURKA	phosphorylation → down-regulates activity	GSK3B/Axin/APC	SIGNOR-227923
CSNK1E	phosphorylation → up-regulates	GSK3B/Axin/APC	SIGNOR-227976