Entity Details

Name GSK3B/Axin/APC
ID SIGNOR-C110
Role substrate
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAPK1GSK3B/Axin/APC–phosphorylation
down-regulates activity		28646232SIGNOR-262521
CSNK1DGSK3B/Axin/APC–phosphorylation
up-regulates		12000790SIGNOR-227970
MAP4K5GSK3B/Axin/APC–phosphorylation
down-regulates activity		16914735SIGNOR-228006
MAPK3GSK3B/Axin/APC–phosphorylation
down-regulates activity		28646232SIGNOR-262520
PPM1AGSK3B/Axin/APC–dephosphorylation
down-regulates		10644691SIGNOR-227955
CDC14BGSK3B/Axin/APC–dephosphorylation
up-regulates		18662541SIGNOR-227927
AKTGSK3B/Axin/APC–phosphorylation
down-regulates activity		16293724SIGNOR-227952
ERK1/2GSK3B/Axin/APC–phosphorylation
down-regulates activity		28646232SIGNOR-262519
CSNK1EGSK3B/Axin/APC–phosphorylation
up-regulates		12000790SIGNOR-227976
GbetaGSK3B/Axin/APC–phosphorylation
down-regulates activity		28646232SIGNOR-270068
AURKAGSK3B/Axin/APC–phosphorylation
down-regulates activity		19060929SIGNOR-227923
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
Regulator Mechanism/Effect Target SIGNOR-ID
MAPK1phosphorylation
→
down-regulates activity 		GSK3B/Axin/APCSIGNOR-262521
CSNK1Dphosphorylation
→
up-regulates 		GSK3B/Axin/APCSIGNOR-227970
MAP4K5phosphorylation
→
down-regulates activity 		GSK3B/Axin/APCSIGNOR-228006
MAPK3phosphorylation
→
down-regulates activity 		GSK3B/Axin/APCSIGNOR-262520
PPM1Adephosphorylation
img/direct_inhibition.png
down-regulates 		GSK3B/Axin/APCSIGNOR-227955
CDC14Bdephosphorylation
→
up-regulates 		GSK3B/Axin/APCSIGNOR-227927
AKTphosphorylation
→
down-regulates activity 		GSK3B/Axin/APCSIGNOR-227952
ERK1/2phosphorylation
→
down-regulates activity 		GSK3B/Axin/APCSIGNOR-262519
CSNK1Ephosphorylation
→
up-regulates 		GSK3B/Axin/APCSIGNOR-227976
Gbetaphosphorylation
→
down-regulates activity 		GSK3B/Axin/APCSIGNOR-270068
AURKAphosphorylation
→
down-regulates activity 		GSK3B/Axin/APCSIGNOR-227923