| Name | NfKb-p65/p50 |
| ID | SIGNOR-C13 |
| Role | substrate |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKE | NfKb-p65/p50 | – | phosphorylation up-regulates activity | 15489227 | SIGNOR-217379 | |
| IKBKB | NfKb-p65/p50 | – | phosphorylation unknown | 15489227 | SIGNOR-217376 | |
| RPS6KA5 | NfKb-p65/p50 | – | phosphorylation up-regulates | 12628924 | SIGNOR-217424 | |
| IKBKB | NfKb-p65/p50 | – | phosphorylation down-regulates | 11158290 | SIGNOR-217403 | |
| GSK3B | NfKb-p65/p50 | – | phosphorylation up-regulates | 17183360 | SIGNOR-217367 | |
| PRKACA | NfKb-p65/p50 | – | phosphorylation up-regulates | 17959673 | SIGNOR-217391 | |
| GSK3B | NfKb-p65/p50 | – | phosphorylation up-regulates | 16407239 | SIGNOR-217430 | |
| IKBKB | NfKb-p65/p50 | – | phosphorylation unknown | 16046471 | SIGNOR-217427 | |
| TBK1 | NfKb-p65/p50 | – | phosphorylation up-regulates activity | 15489227 | SIGNOR-260157 | |
| PRKCZ | NfKb-p65/p50 | – | phosphorylation up-regulates | 17183360 | SIGNOR-217370 | |
| IKK-complex | NfKb-p65/p50 | – | phosphorylation up-regulates | 15489227 | SIGNOR-216341 | |
| IKK-complex | NfKb-p65/p50 | – | phosphorylation up-regulates | 19609947 | SIGNOR-216365 | |
| PPP2CA | NfKb-p65/p50 | – | dephosphorylation down-regulates | 11591705 | SIGNOR-217421 | |
| IKBKB | NfKb-p65/p50 | – | phosphorylation down-regulates | 10469655 | SIGNOR-217400 | |
| RPS6KA4 | NfKb-p65/p50 | – | phosphorylation up-regulates | 17183360 | SIGNOR-217373 | |
| IKBKG | NfKb-p65/p50 | – | phosphorylation up-regulates | 15489227 | SIGNOR-217382 | |
| PRKACA | NfKb-p65/p50 | – | phosphorylation up-regulates | 9660950 | SIGNOR-217364 | |
| CHUK | NfKb-p65/p50 | – | phosphorylation down-regulates | 10469655 | SIGNOR-217397 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKE | phosphorylation → up-regulates activity | NfKb-p65/p50 | SIGNOR-217379 |
| IKBKB | phosphorylation → unknown | NfKb-p65/p50 | SIGNOR-217376 |
| RPS6KA5 | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-217424 |
| IKBKB | phosphorylation down-regulates | NfKb-p65/p50 | SIGNOR-217403 |
| GSK3B | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-217367 |
| PRKACA | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-217391 |
| GSK3B | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-217430 |
| IKBKB | phosphorylation → unknown | NfKb-p65/p50 | SIGNOR-217427 |
| TBK1 | phosphorylation → up-regulates activity | NfKb-p65/p50 | SIGNOR-260157 |
| PRKCZ | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-217370 |
| IKK-complex | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-216341 |
| IKK-complex | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-216365 |
| PPP2CA | dephosphorylation down-regulates | NfKb-p65/p50 | SIGNOR-217421 |
| IKBKB | phosphorylation down-regulates | NfKb-p65/p50 | SIGNOR-217400 |
| RPS6KA4 | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-217373 |
| IKBKG | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-217382 |
| PRKACA | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-217364 |
| CHUK | phosphorylation down-regulates | NfKb-p65/p50 | SIGNOR-217397 |