Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PP2CA_R1A_R2A	RAF1	Ser259	SQRQRSTsTPNVHMV	dephosphorylation up-regulates activity	16239230	SIGNOR-243534
PP2CA_R1A_R2A	DCK	Ser74	EFEELTMsQKNGGNV	dephosphorylation down-regulates activity	24462681	SIGNOR-275804
PP2CA_R1A_R2A	AKT1	Thr308	KDGATMKtFCGTPEY	dephosphorylation down-regulates activity	18042541	SIGNOR-252613
PP2CA_R1A_R2A	MASTL	Thr194	NMMDILTtPSMAKPR	dephosphorylation down-regulates activity	24391510	SIGNOR-276615
PP2CA_R1A_R2A	PPME1	Ser15	MHLGRLPsRPPLPGS	dephosphorylation up-regulates activity	24841198	SIGNOR-265752
PP2CA_R1A_R2A	AKT	–		dephosphorylation down-regulates activity	18042541	SIGNOR-243530

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PP2CA_R1A_R2A	dephosphorylation down-regulates ⊣	RAF1 PSer259	dephosphorylation down-regulates ⊣	RAF1	16239230	SIGNOR-243534
PP2CA_R1A_R2A	dephosphorylation down-regulates ⊣	DCK PSer74	dephosphorylation up-regulates →	DCK	24462681	SIGNOR-275804
PP2CA_R1A_R2A	dephosphorylation down-regulates ⊣	AKT1 PThr308	dephosphorylation up-regulates →	AKT1	18042541	SIGNOR-252613
PP2CA_R1A_R2A	dephosphorylation down-regulates ⊣	MASTL PThr194	dephosphorylation up-regulates →	MASTL	24391510	SIGNOR-276615
PP2CA_R1A_R2A	dephosphorylation down-regulates ⊣	PPME1 PSer15	dephosphorylation down-regulates ⊣	PPME1	24841198	SIGNOR-265752

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PP2CA_R1A_R2A	dephosphorylation → up-regulates activity	RAF1	SIGNOR-243534
PP2CA_R1A_R2A	dephosphorylation → down-regulates activity	DCK	SIGNOR-275804
PP2CA_R1A_R2A	dephosphorylation → down-regulates activity	AKT1	SIGNOR-252613
PP2CA_R1A_R2A	dephosphorylation → down-regulates activity	MASTL	SIGNOR-276615
PP2CA_R1A_R2A	dephosphorylation → up-regulates activity	PPME1	SIGNOR-265752
PP2CA_R1A_R2A	dephosphorylation → down-regulates activity	AKT	SIGNOR-243530