| Name | IKK-complex |
| ID | SIGNOR-C14 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKK-complex | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-216407 |
| IKK-complex | FOXO3 | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates quantity by destabilization | 19188143 | SIGNOR-209769 |
| IKK-complex | NFKBIA | – | phosphorylation down-regulates | 21232017 | SIGNOR-216396 | |
| IKK-complex | NFKBIA | Ser32 | LLDDRHDsGLDSMKD | phosphorylation down-regulates | 9346241 | SIGNOR-216385 |
| IKK-complex | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates | 9346241 | SIGNOR-216389 |
| IKK-complex | NFKBIA | Ser36 | RHDSGLDsMKDEEYE | phosphorylation down-regulates quantity by destabilization | 9346241 | SIGNOR-209773 |
| IKK-complex | MTURN | Ser58 | GDNFHVWsESEDCLP | phosphorylation down-regulates activity | 28704656 | SIGNOR-273641 |
| IKK-complex | BAD | – | phosphorylation down-regulates | 23332762 | SIGNOR-216399 | |
| IKK-complex | BAD | Ser25 | AERGLGPsPAGDGPS | phosphorylation down-regulates activity | 23332762 | SIGNOR-209776 |
| IKK-complex | CYLD | Ser418 | TTENRFHsLPFSLTK | phosphorylation down-regulates activity | 15870263 | SIGNOR-266435 |
| IKK-complex | NCOR2 | Ser2407 | AKVSGRPsSRKAKSP | phosphorylation down-regulates | 15494311 | SIGNOR-216393 |
| IKK-complex | IKBKG | Ser68 | LRDAIRQsNQILRER | phosphorylation down-regulates activity | 17977820 | SIGNOR-209788 |
| IKK-complex | IKBKG | Ser85 | ELLHFQAsQREEKEF | phosphorylation down-regulates activity | 17977820 | SIGNOR-209784 |
| IKK-complex | IKBKG | Ser376 | PPAPAYLsSPLALPS | phosphorylation unknown | 12657630 | SIGNOR-209792 |
| IKK-complex | IKBKG | Ser43 | PAMLHLPsEQGAPET | phosphorylation unknown | 17977820 | SIGNOR-216403 |
| IKK-complex | NfKb-p65/p50 | – | phosphorylation up-regulates | 15489227 | SIGNOR-216341 | |
| IKK-complex | NfKb-p65/p50 | – | phosphorylation up-regulates | 19609947 | SIGNOR-216365 | |
| IKK-complex | IKK-complex | – | phosphorylation down-regulates | 10195894 | SIGNOR-216373 | |
| IKK-complex | FOXO | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates | 15084260 | SIGNOR-252950 |
| IKK-complex | FOXO | Ser644 | GLDFNFDsLISTQNV | phosphorylation down-regulates quantity by destabilization | 19188143 | SIGNOR-252951 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKK-complex | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 15084260 | SIGNOR-216407 |
| IKK-complex | phosphorylation up-regulates → | FOXO3 PSer644 | phosphorylation down-regulates ⊣ | FOXO3 | 19188143 | SIGNOR-209769 |
| IKK-complex | phosphorylation up-regulates → | NFKBIA PSer32 | phosphorylation down-regulates ⊣ | NFKBIA | 9346241 | SIGNOR-216385 |
| IKK-complex | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 9346241 | SIGNOR-216389 |
| IKK-complex | phosphorylation up-regulates → | NFKBIA PSer36 | phosphorylation down-regulates ⊣ | NFKBIA | 9346241 | SIGNOR-209773 |
| IKK-complex | phosphorylation up-regulates → | MTURN PSer58 | phosphorylation down-regulates ⊣ | MTURN | 28704656 | SIGNOR-273641 |
| IKK-complex | phosphorylation up-regulates → | BAD PSer25 | phosphorylation down-regulates ⊣ | BAD | 23332762 | SIGNOR-209776 |
| IKK-complex | phosphorylation up-regulates → | CYLD PSer418 | phosphorylation down-regulates ⊣ | CYLD | 15870263 | SIGNOR-266435 |
| IKK-complex | phosphorylation up-regulates → | NCOR2 PSer2407 | phosphorylation down-regulates ⊣ | NCOR2 | 15494311 | SIGNOR-216393 |
| IKK-complex | phosphorylation up-regulates → | IKBKG PSer68 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-209788 |
| IKK-complex | phosphorylation up-regulates → | IKBKG PSer85 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-209784 |
| IKK-complex | phosphorylation up-regulates → | IKBKG PSer376 | phosphorylation down-regulates ⊣ | IKBKG | 12657630 | SIGNOR-209792 |
| IKK-complex | phosphorylation up-regulates → | IKBKG PSer43 | phosphorylation down-regulates ⊣ | IKBKG | 17977820 | SIGNOR-216403 |
| IKK-complex | phosphorylation up-regulates → | FOXO PSer644 | phosphorylation down-regulates ⊣ | FOXO | 15084260 | SIGNOR-252950 |
| IKK-complex | phosphorylation up-regulates → | FOXO PSer644 | phosphorylation down-regulates ⊣ | FOXO | 19188143 | SIGNOR-252951 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKK-complex | phosphorylation down-regulates | FOXO3 | SIGNOR-216407 |
| IKK-complex | phosphorylation down-regulates quantity by destabilization | FOXO3 | SIGNOR-209769 |
| IKK-complex | phosphorylation down-regulates | NFKBIA | SIGNOR-216396 |
| IKK-complex | phosphorylation down-regulates | NFKBIA | SIGNOR-216385 |
| IKK-complex | phosphorylation down-regulates | NFKBIA | SIGNOR-216389 |
| IKK-complex | phosphorylation down-regulates quantity by destabilization | NFKBIA | SIGNOR-209773 |
| IKK-complex | phosphorylation → down-regulates activity | MTURN | SIGNOR-273641 |
| IKK-complex | phosphorylation down-regulates | BAD | SIGNOR-216399 |
| IKK-complex | phosphorylation → down-regulates activity | BAD | SIGNOR-209776 |
| IKK-complex | phosphorylation → down-regulates activity | CYLD | SIGNOR-266435 |
| IKK-complex | phosphorylation down-regulates | NCOR2 | SIGNOR-216393 |
| IKK-complex | phosphorylation → down-regulates activity | IKBKG | SIGNOR-209788 |
| IKK-complex | phosphorylation → down-regulates activity | IKBKG | SIGNOR-209784 |
| IKK-complex | phosphorylation → unknown | IKBKG | SIGNOR-209792 |
| IKK-complex | phosphorylation → unknown | IKBKG | SIGNOR-216403 |
| IKK-complex | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-216341 |
| IKK-complex | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-216365 |
| IKK-complex | phosphorylation down-regulates | IKK-complex | SIGNOR-216373 |
| IKK-complex | phosphorylation down-regulates | FOXO | SIGNOR-252950 |
| IKK-complex | phosphorylation down-regulates quantity by destabilization | FOXO | SIGNOR-252951 |