Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CyclinD1/CDK6	CTNNB1	Ser45	GATTTAPsLSGKGNP	phosphorylation down-regulates activity	17208333	SIGNOR-250647
CyclinD1/CDK6	TSC2	Ser1217	MSLENPLsPFSSDIN	phosphorylation up-regulates activity	32294430	SIGNOR-274101
CyclinD1/CDK6	TSC2	Ser1452	LPSSSPRsPSGLRPR	phosphorylation up-regulates activity	32294430	SIGNOR-274102
CyclinD1/CDK6	NDEL1	Thr245	GFGTSPLtPSARISA	phosphorylation up-regulates activity	12796778	SIGNOR-250652

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CyclinD1/CDK6	phosphorylation up-regulates →	CTNNB1 PSer45	phosphorylation down-regulates ⊣	CTNNB1	17208333	SIGNOR-250647
CyclinD1/CDK6	phosphorylation up-regulates →	TSC2 PSer1217	phosphorylation up-regulates →	TSC2	32294430	SIGNOR-274101
CyclinD1/CDK6	phosphorylation up-regulates →	TSC2 PSer1452	phosphorylation up-regulates →	TSC2	32294430	SIGNOR-274102
CyclinD1/CDK6	phosphorylation up-regulates →	NDEL1 PThr245	phosphorylation up-regulates →	NDEL1	12796778	SIGNOR-250652

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CyclinD1/CDK6	phosphorylation → down-regulates activity	CTNNB1	SIGNOR-250647
CyclinD1/CDK6	phosphorylation → up-regulates activity	TSC2	SIGNOR-274101
CyclinD1/CDK6	phosphorylation → up-regulates activity	TSC2	SIGNOR-274102
CyclinD1/CDK6	phosphorylation → up-regulates activity	NDEL1	SIGNOR-250652