| Name | CDK5/CDK5R1 |
| ID | SIGNOR-C144 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | DCX | Ser28 | SRMNGLPsPTHSAHC | phosphorylation unknown | 14741103 | SIGNOR-250654 |
| CDK5/CDK5R1 | DCX | Ser287 | ATAGPKAsPTPQKTS | phosphorylation unknown | 14741103 | SIGNOR-250655 |
| CDK5/CDK5R1 | DCX | Ser306 | GPMRRSKsPADSGND | phosphorylation unknown | 14741103 | SIGNOR-250658 |
| CDK5/CDK5R1 | DCX | Ser332 | STPKSKQsPISTPTS | phosphorylation unknown | 14741103 | SIGNOR-250667 |
| CDK5/CDK5R1 | DCX | Ser339 | SPISTPTsPGSLRKH | phosphorylation unknown | 14741103 | SIGNOR-250673 |
| CDK5/CDK5R1 | DCX | Thr289 | AGPKASPtPQKTSAK | phosphorylation unknown | 14741103 | SIGNOR-250656 |
| CDK5/CDK5R1 | DCX | Thr326 | TSSSQLStPKSKQSP | phosphorylation unknown | 14741103 | SIGNOR-250659 |
| CDK5/CDK5R1 | DCX | Thr336 | SKQSPIStPTSPGSL | phosphorylation unknown | 14741103 | SIGNOR-250660 |
| CDK5/CDK5R1 | DCX | Ser297 | PQKTSAKsPGPMRRS | phosphorylation up-regulates activity | 14741103 | SIGNOR-250657 |
| CDK5/CDK5R1 | TP53 | Ser315 | LPNNTSSsPQPKKKP | phosphorylation up-regulates activity | 12064478 | SIGNOR-250674 |
| CDK5/CDK5R1 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates | 12226093 | SIGNOR-251599 |
| CDK5/CDK5R1 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates | 12226093 | SIGNOR-251600 |
| CDK5/CDK5R1 | MAPT | Ser235 | SPQDSPPsKASPAQD | phosphorylation down-regulates | 21215781 | SIGNOR-251587 |
| CDK5/CDK5R1 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates | 21215781 | SIGNOR-251601 |
| CDK5/CDK5R1 | MAPT | Ser516 | GDRSGYSsPGSPGTP | phosphorylation down-regulates activity | 12387894 | SIGNOR-251598 |
| CDK5/CDK5R1 | MAPT | Ser519 | SGYSSPGsPGTPGSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-251588 |
| CDK5/CDK5R1 | MAPT | Ser531 | GSRSRTPsLPTPPTR | phosphorylation down-regulates activity | 12387894 | SIGNOR-251589 |
| CDK5/CDK5R1 | MAPT | Ser552 | VVRTPPKsPSSAKSR | phosphorylation down-regulates activity | 12387894 | SIGNOR-251590 |
| CDK5/CDK5R1 | MAPT | Ser713 | GAEIVYKsPVVSGDT | phosphorylation down-regulates activity | 12387894 | SIGNOR-251591 |
| CDK5/CDK5R1 | MAPT | Ser721 | PVVSGDTsPRHLSNV | phosphorylation down-regulates activity | 12387894 | SIGNOR-251592 |
| CDK5/CDK5R1 | MAPT | Thr498 | KTPPAPKtPPSSGEP | phosphorylation down-regulates activity | 12387894 | SIGNOR-251597 |
| CDK5/CDK5R1 | MAPT | Thr522 | SSPGSPGtPGSRSRT | phosphorylation down-regulates activity | 12387894 | SIGNOR-251593 |
| CDK5/CDK5R1 | MAPT | Thr529 | TPGSRSRtPSLPTPP | phosphorylation down-regulates activity | 12387894 | SIGNOR-251594 |
| CDK5/CDK5R1 | MAPT | Thr534 | SRTPSLPtPPTREPK | phosphorylation down-regulates activity | 12387894 | SIGNOR-251595 |
| CDK5/CDK5R1 | MAPT | Thr548 | KKVAVVRtPPKSPSS | phosphorylation down-regulates activity | 12387894 | SIGNOR-251596 |
| CDK5/CDK5R1 | BACE1 | Thr252 | YTGSLWYtPIRREWY | phosphorylation up-regulates activity | 26317805 | SIGNOR-276934 |
| CDK5/CDK5R1 | MAP2K1 | Thr286 | VEGDAAEtPPRPRTP | phosphorylation down-regulates activity | 11684694 | SIGNOR-250653 |
| CDK5/CDK5R1 | VRK3 | Ser108 | RPPTPKSsPQKTRKS | phosphorylation up-regulates activity | 27346674 | SIGNOR-275545 |
| CDK5/CDK5R1 | NDEL1 | Thr219 | ASLSLPAtPVGKGTE | phosphorylation up-regulates activity | 12796778 | SIGNOR-250678 |
| CDK5/CDK5R1 | SUDS3 | Ser228 | RTLNKLKsPKRPASP | phosphorylation up-regulates activity | 15489224 | SIGNOR-262739 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer28 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250654 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer287 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250655 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer306 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250658 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer332 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250667 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer339 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250673 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PThr289 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250656 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PThr326 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250659 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PThr336 | phosphorylation down-regulates ⊣ | DCX | 14741103 | SIGNOR-250660 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | DCX PSer297 | phosphorylation up-regulates → | DCX | 14741103 | SIGNOR-250657 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | TP53 PSer315 | phosphorylation up-regulates → | TP53 | 12064478 | SIGNOR-250674 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-251599 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12226093 | SIGNOR-251600 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer235 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-251587 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 21215781 | SIGNOR-251601 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer516 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251598 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer519 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251588 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer531 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251589 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer552 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251590 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer713 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251591 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PSer721 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251592 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr498 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251597 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr522 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251593 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr529 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251594 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr534 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251595 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAPT PThr548 | phosphorylation down-regulates ⊣ | MAPT | 12387894 | SIGNOR-251596 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | BACE1 PThr252 | phosphorylation up-regulates → | BACE1 | 26317805 | SIGNOR-276934 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | MAP2K1 PThr286 | phosphorylation down-regulates ⊣ | MAP2K1 | 11684694 | SIGNOR-250653 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | VRK3 PSer108 | phosphorylation up-regulates → | VRK3 | 27346674 | SIGNOR-275545 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | NDEL1 PThr219 | phosphorylation up-regulates → | NDEL1 | 12796778 | SIGNOR-250678 |
| CDK5/CDK5R1 | phosphorylation up-regulates → | SUDS3 PSer228 | phosphorylation up-regulates → | SUDS3 | 15489224 | SIGNOR-262739 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250654 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250655 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250658 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250667 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250673 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250656 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250659 |
| CDK5/CDK5R1 | phosphorylation → unknown | DCX | SIGNOR-250660 |
| CDK5/CDK5R1 | phosphorylation → up-regulates activity | DCX | SIGNOR-250657 |
| CDK5/CDK5R1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-250674 |
| CDK5/CDK5R1 | phosphorylation down-regulates | MAPT | SIGNOR-251599 |
| CDK5/CDK5R1 | phosphorylation down-regulates | MAPT | SIGNOR-251600 |
| CDK5/CDK5R1 | phosphorylation down-regulates | MAPT | SIGNOR-251587 |
| CDK5/CDK5R1 | phosphorylation down-regulates | MAPT | SIGNOR-251601 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251598 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251588 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251589 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251590 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251591 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251592 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251597 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251593 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251594 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251595 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-251596 |
| CDK5/CDK5R1 | phosphorylation → up-regulates activity | BACE1 | SIGNOR-276934 |
| CDK5/CDK5R1 | phosphorylation → down-regulates activity | MAP2K1 | SIGNOR-250653 |
| CDK5/CDK5R1 | phosphorylation → up-regulates activity | VRK3 | SIGNOR-275545 |
| CDK5/CDK5R1 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-250678 |
| CDK5/CDK5R1 | phosphorylation → up-regulates activity | SUDS3 | SIGNOR-262739 |