Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
ERK1/2	AP1	Thr325	TELEPLCtPVVTCTP	phosphorylation up-regulates	12972619	SIGNOR-252357
MAPK8	AP1	Ser63	KNSDLLTsPDVGLLK	phosphorylation up-regulates activity	8137421	SIGNOR-252354
ERK1/2	AP1	Thr232	GGLPEVAtPESEEAF	phosphorylation up-regulates	7816602	SIGNOR-252359
ERK1/2	AP1	Ser374	PSSDSLSsPTLLAL	phosphorylation up-regulates	12972619	SIGNOR-252358
ERK1/2	AP1	Thr331	CTPVVTCtPSCTAYT	phosphorylation up-regulates	12972619	SIGNOR-252353
MAPK8	AP1	Ser73	VGLLKLAsPELERLI	phosphorylation up-regulates activity	8137421	SIGNOR-252355

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
ERK1/2	phosphorylation up-regulates →	AP1 PThr325	phosphorylation up-regulates →	AP1	12972619	SIGNOR-252357
MAPK8	phosphorylation up-regulates →	AP1 PSer63	phosphorylation up-regulates →	AP1	8137421	SIGNOR-252354
ERK1/2	phosphorylation up-regulates →	AP1 PThr232	phosphorylation up-regulates →	AP1	7816602	SIGNOR-252359
ERK1/2	phosphorylation up-regulates →	AP1 PSer374	phosphorylation up-regulates →	AP1	12972619	SIGNOR-252358
ERK1/2	phosphorylation up-regulates →	AP1 PThr331	phosphorylation up-regulates →	AP1	12972619	SIGNOR-252353
MAPK8	phosphorylation up-regulates →	AP1 PSer73	phosphorylation up-regulates →	AP1	8137421	SIGNOR-252355

Regulator	Mechanism/Effect	Target	SIGNOR-ID
ERK1/2	phosphorylation → up-regulates	AP1	SIGNOR-252357
MAPK8	phosphorylation → up-regulates activity	AP1	SIGNOR-252354
ERK1/2	phosphorylation → up-regulates	AP1	SIGNOR-252359
ERK1/2	phosphorylation → up-regulates	AP1	SIGNOR-252358
ERK1/2	phosphorylation → up-regulates	AP1	SIGNOR-252353
MAPK8	phosphorylation → up-regulates activity	AP1	SIGNOR-252355