| Name | Calcineurin |
| ID | SIGNOR-C155 |
| Role | phosphatase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| Calcineurin | DNM1L | Ser637 | VPVARKLsAREQRDC | dephosphorylation up-regulates activity | 18838687 | SIGNOR-252315 |
| Calcineurin | CACNA1H | Ser2137 | RDLRRLYsVDAQGFL | dephosphorylation up-regulates activity | 38001892 | SIGNOR-277872 |
| Calcineurin | NFATC1 | – | dephosphorylation up-regulates | 14722106 | SIGNOR-252313 | |
| Calcineurin | NFATC1 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-252323 | |
| Calcineurin | FLNA | Ser2152 | TRRRRAPsVANVGSH | dephosphorylation down-regulates | 16442073 | SIGNOR-252339 |
| Calcineurin | DNM2 | Ser764 | LQSASSHsPTPQRRP | dephosphorylation unknown | 20496096 | SIGNOR-252317 |
| Calcineurin | NFATC3 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-252312 | |
| Calcineurin | NFATC2 | – | dephosphorylation up-regulates | 18676376 | SIGNOR-252321 | |
| Calcineurin | NFATC2 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-252311 | |
| Calcineurin | NFATC2 | Ser168 | YREPLCLsPASSGSS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252319 |
| Calcineurin | NFATC2 | Ser171 | PLCLSPAsSGSSASF | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252318 |
| Calcineurin | NFATC2 | Ser172 | LCLSPASsGSSASFI | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252316 |
| Calcineurin | NFATC2 | Ser174 | LSPASSGsSASFISD | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252326 |
| Calcineurin | NFATC2 | Ser175 | SPASSGSsASFISDT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252343 |
| Calcineurin | NFATC2 | Ser177 | ASSGSSAsFISDTFS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252325 |
| Calcineurin | NFATC2 | Ser180 | GSSASFIsDTFSPYT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252327 |
| Calcineurin | NFATC2 | Ser213 | QNIPAHYsPRTSPIM | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252329 |
| Calcineurin | NFATC2 | Ser217 | AHYSPRTsPIMSPRT | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252330 |
| Calcineurin | NFATC2 | Ser221 | PRTSPIMsPRTSLAE | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252331 |
| Calcineurin | NFATC2 | Ser268 | VALPPGAsPQRSRSP | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252342 |
| Calcineurin | NFATC2 | Ser274 | ASPQRSRsPSPQPSS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252328 |
| Calcineurin | NFATC2 | Ser276 | PQRSRSPsPQPSSHV | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252333 |
| Calcineurin | NFATC2 | Ser280 | RSPSPQPsSHVAPQD | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252336 |
| Calcineurin | NFATC2 | Ser326 | PPKMWKTsPDPSPVS | dephosphorylation up-regulates activity | 11030334 | SIGNOR-252335 |
| Calcineurin | NFATC2 | – | dephosphorylation up-regulates activity | 21880741 | SIGNOR-255463 | |
| Calcineurin | PPP1R1A | Ser67 | LKSTLAMsPRQRKKM | dephosphorylation unknown | 11278334 | SIGNOR-252334 |
| Calcineurin | NFATC4 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-252322 | |
| Calcineurin | BAD | Ser75 | EIRSRHSsYPAGTED | dephosphorylation up-regulates activity | 10195903 | SIGNOR-252324 |
| Calcineurin | BAD | Ser99 | PFRGRSRsAPPNLWA | dephosphorylation up-regulates activity | 10195903 | SIGNOR-252332 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| Calcineurin | dephosphorylation down-regulates ⊣ | DNM1L PSer637 | dephosphorylation down-regulates ⊣ | DNM1L | 18838687 | SIGNOR-252315 |
| Calcineurin | dephosphorylation down-regulates ⊣ | CACNA1H PSer2137 | dephosphorylation down-regulates ⊣ | CACNA1H | 38001892 | SIGNOR-277872 |
| Calcineurin | dephosphorylation down-regulates ⊣ | FLNA PSer2152 | dephosphorylation up-regulates → | FLNA | 16442073 | SIGNOR-252339 |
| Calcineurin | dephosphorylation down-regulates ⊣ | DNM2 PSer764 | dephosphorylation up-regulates → | DNM2 | 20496096 | SIGNOR-252317 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer168 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252319 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer171 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252318 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer172 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252316 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer174 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252326 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer175 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252343 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer177 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252325 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer180 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252327 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer213 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252329 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer217 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252330 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer221 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252331 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer268 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252342 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer274 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252328 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer276 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252333 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer280 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252336 |
| Calcineurin | dephosphorylation down-regulates ⊣ | NFATC2 PSer326 | dephosphorylation down-regulates ⊣ | NFATC2 | 11030334 | SIGNOR-252335 |
| Calcineurin | dephosphorylation down-regulates ⊣ | PPP1R1A PSer67 | dephosphorylation up-regulates → | PPP1R1A | 11278334 | SIGNOR-252334 |
| Calcineurin | dephosphorylation down-regulates ⊣ | BAD PSer75 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-252324 |
| Calcineurin | dephosphorylation down-regulates ⊣ | BAD PSer99 | dephosphorylation down-regulates ⊣ | BAD | 10195903 | SIGNOR-252332 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| Calcineurin | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-252315 |
| Calcineurin | dephosphorylation → up-regulates activity | CACNA1H | SIGNOR-277872 |
| Calcineurin | dephosphorylation → up-regulates | NFATC1 | SIGNOR-252313 |
| Calcineurin | dephosphorylation → up-regulates | NFATC1 | SIGNOR-252323 |
| Calcineurin | dephosphorylation down-regulates | FLNA | SIGNOR-252339 |
| Calcineurin | dephosphorylation → unknown | DNM2 | SIGNOR-252317 |
| Calcineurin | dephosphorylation → up-regulates | NFATC3 | SIGNOR-252312 |
| Calcineurin | dephosphorylation → up-regulates | NFATC2 | SIGNOR-252321 |
| Calcineurin | dephosphorylation → up-regulates | NFATC2 | SIGNOR-252311 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252319 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252318 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252316 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252326 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252343 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252325 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252327 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252329 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252330 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252331 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252342 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252328 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252333 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252336 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-252335 |
| Calcineurin | dephosphorylation → up-regulates activity | NFATC2 | SIGNOR-255463 |
| Calcineurin | dephosphorylation → unknown | PPP1R1A | SIGNOR-252334 |
| Calcineurin | dephosphorylation → up-regulates | NFATC4 | SIGNOR-252322 |
| Calcineurin | dephosphorylation → up-regulates activity | BAD | SIGNOR-252324 |
| Calcineurin | dephosphorylation → up-regulates activity | BAD | SIGNOR-252332 |