Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
LCK	PI3K	Tyr688	FAEPYNLySSLKELV	phosphorylation down-regulates activity	9461588	SIGNOR-252699
KIT	PI3K	–		phosphorylation up-regulates activity	15526160	SIGNOR-254949
IFNAR1	PI3K	–		phosphorylation up-regulates activity	21631354	SIGNOR-260435
PPM1A	PI3K	Ser608	ENTEDQYsLVEDDED	dephosphorylation up-regulates activity	15016818	SIGNOR-252724
INSR	PI3K	Tyr368	STKMHGDyTLTLRKG	phosphorylation up-regulates activity	8385099	SIGNOR-252692
INSR	PI3K	Tyr607	NENTEDQySLVEDDE	phosphorylation up-regulates activity	8385099	SIGNOR-252693
PTPRJ	PI3K	–		dephosphorylation down-regulates	18348712	SIGNOR-252727
INSR	PI3K	Tyr580	LRKTRDQyLMWLTQK	phosphorylation up-regulates activity	8385099	SIGNOR-252691

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
LCK	phosphorylation up-regulates →	PI3K PTyr688	phosphorylation down-regulates ⊣	PI3K	9461588	SIGNOR-252699
PPM1A	dephosphorylation down-regulates ⊣	PI3K PSer608	dephosphorylation down-regulates ⊣	PI3K	15016818	SIGNOR-252724
INSR	phosphorylation up-regulates →	PI3K PTyr368	phosphorylation up-regulates →	PI3K	8385099	SIGNOR-252692
INSR	phosphorylation up-regulates →	PI3K PTyr607	phosphorylation up-regulates →	PI3K	8385099	SIGNOR-252693
INSR	phosphorylation up-regulates →	PI3K PTyr580	phosphorylation up-regulates →	PI3K	8385099	SIGNOR-252691

Regulator	Mechanism/Effect	Target	SIGNOR-ID
LCK	phosphorylation → down-regulates activity	PI3K	SIGNOR-252699
KIT	phosphorylation → up-regulates activity	PI3K	SIGNOR-254949
IFNAR1	phosphorylation → up-regulates activity	PI3K	SIGNOR-260435
PPM1A	dephosphorylation → up-regulates activity	PI3K	SIGNOR-252724
INSR	phosphorylation → up-regulates activity	PI3K	SIGNOR-252692
INSR	phosphorylation → up-regulates activity	PI3K	SIGNOR-252693
PTPRJ	dephosphorylation down-regulates	PI3K	SIGNOR-252727
INSR	phosphorylation → up-regulates activity	PI3K	SIGNOR-252691