| Name | CyclinE/CDK2 |
| ID | SIGNOR-C16 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | CDC7 | Thr376 | QVAPRAGtPGFRAPE | phosphorylation up-regulates activity | 10846177 | SIGNOR-250726 |
| CyclinE/CDK2 | TP73 | Thr86 | AASASPYtPEHAASV | phosphorylation down-regulates | 12676926 | SIGNOR-216702 |
| CyclinE/CDK2 | SNAI2 | Ser104 | KDHSGSEsPISDEEE | phosphorylation down-regulates quantity by destabilization | 24662826 | SIGNOR-276629 |
| CyclinE/CDK2 | SNAI2 | Ser54 | ILSSGAYsPITVWTT | phosphorylation down-regulates quantity by destabilization | 24662826 | SIGNOR-276628 |
| CyclinE/CDK2 | PRC1 | Thr470 | LYGSAPRtPSKRRGL | phosphorylation unknown | 9885575 | SIGNOR-250745 |
| CyclinE/CDK2 | PRC1 | Thr481 | RRGLAPNtPGKARKL | phosphorylation unknown | 9885575 | SIGNOR-250746 |
| CyclinE/CDK2 | SF3B1 | Thr313 | HGSGWAEtPRTDRGG | phosphorylation unknown | 12105215 | SIGNOR-216717 |
| CyclinE/CDK2 | SF3B1 | Thr244 | GRAKGSEtPGATPGS | phosphorylation up-regulates | 12105215 | SIGNOR-216686 |
| CyclinE/CDK2 | SF3B1 | Thr248 | GSETPGAtPGSKIWD | phosphorylation up-regulates | 12105215 | SIGNOR-216666 |
| CyclinE/CDK2 | RB1 | Ser608 | TAADMYLsPVRSPKK | phosphorylation down-regulates activity | 10207050 | SIGNOR-250747 |
| CyclinE/CDK2 | NPM1 | Thr199 | VKKSIRDtPAKNAQK | phosphorylation down-regulates activity | 11278991 | SIGNOR-250744 |
| CyclinE/CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 11278991 | SIGNOR-216674 |
| CyclinE/CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 12058066 | SIGNOR-216662 |
| CyclinE/CDK2 | NPM1 | Thr234 | SFKKQEKtPKTPKGP | phosphorylation down-regulates activity | 14670079 | SIGNOR-216690 |
| CyclinE/CDK2 | PRKAR1A | Ser83 | DSREDEIsPPPPNPV | phosphorylation up-regulates | 16582606 | SIGNOR-216729 |
| CyclinE/CDK2 | UNG | Ser12 | KTLYSFFsPSPARKR | phosphorylation up-regulates activity | 18079698 | SIGNOR-276098 |
| CyclinE/CDK2 | UNG | Ser14 | LYSFFSPsPARKRHA | phosphorylation up-regulates activity | 18079698 | SIGNOR-276100 |
| CyclinE/CDK2 | UNG | Ser23 | ARKRHAPsPEPAVQG | phosphorylation up-regulates activity | 18079698 | SIGNOR-276097 |
| CyclinE/CDK2 | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation up-regulates activity | 18079698 | SIGNOR-276099 |
| CyclinE/CDK2 | MYOD1 | Ser200 | YSGDSDAsSPRSNCS | phosphorylation down-regulates | 21902831 | SIGNOR-216706 |
| CyclinE/CDK2 | UBTF | Ser389 | INKKQATsPASKKPA | phosphorylation up-regulates | 11698641 | SIGNOR-216678 |
| CyclinE/CDK2 | UBTF | Ser484 | ERGKLPEsPKRAEEI | phosphorylation up-regulates activity | 10202152 | SIGNOR-250755 |
| CyclinE/CDK2 | MCM3 | Thr722 | EEMPQVHtPKTADSQ | phosphorylation up-regulates | 21965652 | SIGNOR-216694 |
| CyclinE/CDK2 | CDC25C | Ser214 | SRSGLYRsPSMPENL | phosphorylation up-regulates | 20530684 | SIGNOR-216721 |
| CyclinE/CDK2 | COIL | Ser184 | NEEAKRKsPKKKEKC | phosphorylation up-regulates | 11102515 | SIGNOR-216733 |
| CyclinE/CDK2 | HIRA | Thr555 | LSPSVLTtPSKIEPM | phosphorylation up-regulates | 11238922 | SIGNOR-216670 |
| CyclinE/CDK2 | POU5F1 | Ser12 | LASDFAFsPPPGGGG | phosphorylation up-regulates quantity by stabilization | 31306665 | SIGNOR-264438 |
| CyclinE/CDK2 | POU5F1 | Ser12 | LASDFAFsPPPGGGG | phosphorylation up-regulates quantity by stabilization | 31306665 | SIGNOR-264437 |
| CyclinE/CDK2 | POU5F1 | Ser12 | LASDFAFsPPPGGGG | phosphorylation up-regulates quantity by stabilization | 31306665 | SIGNOR-264436 |
| CyclinE/CDK2 | ID2 | Ser5 | sPVRSVRK | phosphorylation down-regulates | 9029153 | SIGNOR-216698 |
| CyclinE/CDK2 | TFCP2 | Ser309 | SLGEGNGsPNHQPEP | phosphorylation down-regulates | 19237534 | SIGNOR-216713 |
| CyclinE/CDK2 | E2F5 | Thr261 | SQSLTPVtPQKSSMA | phosphorylation up-regulates activity | 10783242 | SIGNOR-262732 |
| CyclinE/CDK2 | PARP10 | Thr101 | QGLPPGTtPQRLEQH | phosphorylation up-regulates activity | 16455663 | SIGNOR-273594 |
| CyclinE/CDK2 | TICRR | Ser1001 | DIGVVEEsPEKGDEI | phosphorylation up-regulates activity | 21646402 | SIGNOR-273600 |
| CyclinE/CDK2 | USP37 | Ser628 | MVNSCITsPSTPSKK | phosphorylation up-regulates activity | 21596315 | SIGNOR-265053 |
| CyclinE/CDK2 | SIRT2 | Ser368 | PNPSTSAsPKKSPPP | phosphorylation down-regulates | 18332217 | SIGNOR-216725 |
| CyclinE/CDK2 | RRN3 | Ser44 | LENDFFNsPPRKTVR | phosphorylation up-regulates | 15004009 | SIGNOR-216682 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinE/CDK2 | phosphorylation up-regulates → | CDC7 PThr376 | phosphorylation up-regulates → | CDC7 | 10846177 | SIGNOR-250726 |
| CyclinE/CDK2 | phosphorylation up-regulates → | TP73 PThr86 | phosphorylation down-regulates ⊣ | TP73 | 12676926 | SIGNOR-216702 |
| CyclinE/CDK2 | phosphorylation up-regulates → | SNAI2 PSer104 | phosphorylation down-regulates ⊣ | SNAI2 | 24662826 | SIGNOR-276629 |
| CyclinE/CDK2 | phosphorylation up-regulates → | SNAI2 PSer54 | phosphorylation down-regulates ⊣ | SNAI2 | 24662826 | SIGNOR-276628 |
| CyclinE/CDK2 | phosphorylation up-regulates → | PRC1 PThr470 | phosphorylation down-regulates ⊣ | PRC1 | 9885575 | SIGNOR-250745 |
| CyclinE/CDK2 | phosphorylation up-regulates → | PRC1 PThr481 | phosphorylation down-regulates ⊣ | PRC1 | 9885575 | SIGNOR-250746 |
| CyclinE/CDK2 | phosphorylation up-regulates → | SF3B1 PThr313 | phosphorylation down-regulates ⊣ | SF3B1 | 12105215 | SIGNOR-216717 |
| CyclinE/CDK2 | phosphorylation up-regulates → | SF3B1 PThr244 | phosphorylation up-regulates → | SF3B1 | 12105215 | SIGNOR-216686 |
| CyclinE/CDK2 | phosphorylation up-regulates → | SF3B1 PThr248 | phosphorylation up-regulates → | SF3B1 | 12105215 | SIGNOR-216666 |
| CyclinE/CDK2 | phosphorylation up-regulates → | RB1 PSer608 | phosphorylation down-regulates ⊣ | RB1 | 10207050 | SIGNOR-250747 |
| CyclinE/CDK2 | phosphorylation up-regulates → | NPM1 PThr199 | phosphorylation down-regulates ⊣ | NPM1 | 11278991 | SIGNOR-250744 |
| CyclinE/CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 11278991 | SIGNOR-216674 |
| CyclinE/CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 12058066 | SIGNOR-216662 |
| CyclinE/CDK2 | phosphorylation up-regulates → | NPM1 PThr234 | phosphorylation down-regulates ⊣ | NPM1 | 14670079 | SIGNOR-216690 |
| CyclinE/CDK2 | phosphorylation up-regulates → | PRKAR1A PSer83 | phosphorylation up-regulates → | PRKAR1A | 16582606 | SIGNOR-216729 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UNG PSer12 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276098 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UNG PSer14 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276100 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UNG PSer23 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276097 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UNG PThr60 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276099 |
| CyclinE/CDK2 | phosphorylation up-regulates → | MYOD1 PSer200 | phosphorylation down-regulates ⊣ | MYOD1 | 21902831 | SIGNOR-216706 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UBTF PSer389 | phosphorylation up-regulates → | UBTF | 11698641 | SIGNOR-216678 |
| CyclinE/CDK2 | phosphorylation up-regulates → | UBTF PSer484 | phosphorylation up-regulates → | UBTF | 10202152 | SIGNOR-250755 |
| CyclinE/CDK2 | phosphorylation up-regulates → | MCM3 PThr722 | phosphorylation up-regulates → | MCM3 | 21965652 | SIGNOR-216694 |
| CyclinE/CDK2 | phosphorylation up-regulates → | CDC25C PSer214 | phosphorylation up-regulates → | CDC25C | 20530684 | SIGNOR-216721 |
| CyclinE/CDK2 | phosphorylation up-regulates → | COIL PSer184 | phosphorylation up-regulates → | COIL | 11102515 | SIGNOR-216733 |
| CyclinE/CDK2 | phosphorylation up-regulates → | HIRA PThr555 | phosphorylation up-regulates → | HIRA | 11238922 | SIGNOR-216670 |
| CyclinE/CDK2 | phosphorylation up-regulates → | POU5F1 PSer12 | phosphorylation up-regulates → | POU5F1 | 31306665 | SIGNOR-264438 |
| CyclinE/CDK2 | phosphorylation up-regulates → | POU5F1 PSer12 | phosphorylation up-regulates → | POU5F1 | 31306665 | SIGNOR-264437 |
| CyclinE/CDK2 | phosphorylation up-regulates → | POU5F1 PSer12 | phosphorylation up-regulates → | POU5F1 | 31306665 | SIGNOR-264436 |
| CyclinE/CDK2 | phosphorylation up-regulates → | ID2 PSer5 | phosphorylation down-regulates ⊣ | ID2 | 9029153 | SIGNOR-216698 |
| CyclinE/CDK2 | phosphorylation up-regulates → | TFCP2 PSer309 | phosphorylation down-regulates ⊣ | TFCP2 | 19237534 | SIGNOR-216713 |
| CyclinE/CDK2 | phosphorylation up-regulates → | E2F5 PThr261 | phosphorylation up-regulates → | E2F5 | 10783242 | SIGNOR-262732 |
| CyclinE/CDK2 | phosphorylation up-regulates → | PARP10 PThr101 | phosphorylation up-regulates → | PARP10 | 16455663 | SIGNOR-273594 |
| CyclinE/CDK2 | phosphorylation up-regulates → | TICRR PSer1001 | phosphorylation up-regulates → | TICRR | 21646402 | SIGNOR-273600 |
| CyclinE/CDK2 | phosphorylation up-regulates → | USP37 PSer628 | phosphorylation up-regulates → | USP37 | 21596315 | SIGNOR-265053 |
| CyclinE/CDK2 | phosphorylation up-regulates → | SIRT2 PSer368 | phosphorylation down-regulates ⊣ | SIRT2 | 18332217 | SIGNOR-216725 |
| CyclinE/CDK2 | phosphorylation up-regulates → | RRN3 PSer44 | phosphorylation up-regulates → | RRN3 | 15004009 | SIGNOR-216682 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinE/CDK2 | phosphorylation → up-regulates activity | CDC7 | SIGNOR-250726 |
| CyclinE/CDK2 | phosphorylation down-regulates | TP73 | SIGNOR-216702 |
| CyclinE/CDK2 | phosphorylation down-regulates quantity by destabilization | SNAI2 | SIGNOR-276629 |
| CyclinE/CDK2 | phosphorylation down-regulates quantity by destabilization | SNAI2 | SIGNOR-276628 |
| CyclinE/CDK2 | phosphorylation → unknown | PRC1 | SIGNOR-250745 |
| CyclinE/CDK2 | phosphorylation → unknown | PRC1 | SIGNOR-250746 |
| CyclinE/CDK2 | phosphorylation → unknown | SF3B1 | SIGNOR-216717 |
| CyclinE/CDK2 | phosphorylation → up-regulates | SF3B1 | SIGNOR-216686 |
| CyclinE/CDK2 | phosphorylation → up-regulates | SF3B1 | SIGNOR-216666 |
| CyclinE/CDK2 | phosphorylation → down-regulates activity | RB1 | SIGNOR-250747 |
| CyclinE/CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-250744 |
| CyclinE/CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216674 |
| CyclinE/CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216662 |
| CyclinE/CDK2 | phosphorylation → down-regulates activity | NPM1 | SIGNOR-216690 |
| CyclinE/CDK2 | phosphorylation → up-regulates | PRKAR1A | SIGNOR-216729 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276098 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276100 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276097 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | UNG | SIGNOR-276099 |
| CyclinE/CDK2 | phosphorylation down-regulates | MYOD1 | SIGNOR-216706 |
| CyclinE/CDK2 | phosphorylation → up-regulates | UBTF | SIGNOR-216678 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | UBTF | SIGNOR-250755 |
| CyclinE/CDK2 | phosphorylation → up-regulates | MCM3 | SIGNOR-216694 |
| CyclinE/CDK2 | phosphorylation → up-regulates | CDC25C | SIGNOR-216721 |
| CyclinE/CDK2 | phosphorylation → up-regulates | COIL | SIGNOR-216733 |
| CyclinE/CDK2 | phosphorylation → up-regulates | HIRA | SIGNOR-216670 |
| CyclinE/CDK2 | phosphorylation → up-regulates quantity by stabilization | POU5F1 | SIGNOR-264438 |
| CyclinE/CDK2 | phosphorylation → up-regulates quantity by stabilization | POU5F1 | SIGNOR-264437 |
| CyclinE/CDK2 | phosphorylation → up-regulates quantity by stabilization | POU5F1 | SIGNOR-264436 |
| CyclinE/CDK2 | phosphorylation down-regulates | ID2 | SIGNOR-216698 |
| CyclinE/CDK2 | phosphorylation down-regulates | TFCP2 | SIGNOR-216713 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | E2F5 | SIGNOR-262732 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | PARP10 | SIGNOR-273594 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | TICRR | SIGNOR-273600 |
| CyclinE/CDK2 | phosphorylation → up-regulates activity | USP37 | SIGNOR-265053 |
| CyclinE/CDK2 | phosphorylation down-regulates | SIRT2 | SIGNOR-216725 |
| CyclinE/CDK2 | phosphorylation → up-regulates | RRN3 | SIGNOR-216682 |