Entity Details

Name CyclinB/CDK1
ID SIGNOR-C17
Role kinase
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CyclinB/CDK1KAT5Ser90LPGSRPGsPEREVPAphosphorylation
up-regulates activity
12468530SIGNOR-250642
CyclinB/CDK1CDC25ASer116PQKLLGCsPALKRSHphosphorylation
up-regulates
12411508SIGNOR-216761
CyclinB/CDK1CASP8Ser387YLEMDLSsPQTRYIPphosphorylation
down-regulates
20937773SIGNOR-216737
CyclinB/CDK1SQSTM1Ser272RSRLTPVsPESSSTEphosphorylation
up-regulates
20974803SIGNOR-216932
CyclinB/CDK1RUNX1Ser397SMVGGERsPPRILPPphosphorylation
up-regulates
21059642SIGNOR-216912
CyclinB/CDK1NME1Ser120GRNIIHGsDSVESAEphosphorylation
up-regulates
18234856SIGNOR-216825
CyclinB/CDK1FERMT2Ser186YSSPGLYsKTMTPTYphosphorylation
down-regulates quantity by destabilization
35469017SIGNOR-276714
CyclinB/CDK1NCOA3Ser728VVKQEQLsPKKKENNphosphorylation
down-regulates
22163316SIGNOR-216892
CyclinB/CDK1SIRT3Thr150MVGAGIStPSGIPDFphosphorylation
up-regulates activity
26141949SIGNOR-276922
CyclinB/CDK1USP9XSer2547YEGSEEVsPPQTKDQphosphorylation
up-regulates activity
32152317SIGNOR-275612
CyclinB/CDK1AMPHSer285NHTLAPAsPAPARPRphosphorylation
unknown
11113134SIGNOR-250646
CyclinB/CDK1FERMT2Ser180PGSGSIYsSPGLYSKphosphorylation
down-regulates quantity by destabilization
35469017SIGNOR-276715
CyclinB/CDK1NPM1Thr234SFKKQEKtPKTPKGPphosphorylation
down-regulates activity
12058066SIGNOR-216745
CyclinB/CDK1CKAP2Thr623FKELKFLtPVRRSRRphosphorylation
up-regulates
19369249SIGNOR-216829
CyclinB/CDK1NDE1Thr243LDDSTGGtPLTPAARphosphorylation
up-regulates quantity by stabilization
16682949SIGNOR-274084
CyclinB/CDK1NDUFV3Ser105QPSSGREsPRHphosphorylation
up-regulates activity
24746669SIGNOR-275601
CyclinB/CDK1FERMT2Ser175GPLITPGsGSIYSSPphosphorylation
down-regulates quantity by destabilization
35469017SIGNOR-276716
CyclinB/CDK1ARHGEF2Ser960SRLSPPHsPRDFTRMphosphorylation
down-regulates activity
17488622SIGNOR-276060
CyclinB/CDK1MEF2CSer396NIKSEPVsPPRDRTTphosphorylation
down-regulates activity
16478538SIGNOR-250719
CyclinB/CDK1RANGAP1Ser428EPAPVLSsPPPADVSphosphorylation
up-regulates
15037602SIGNOR-216781
CyclinB/CDK1FOXM1Ser251MIQFAINsTERKRMTphosphorylation
up-regulates
19737929SIGNOR-216833
CyclinB/CDK1NPM1Thr237KQEKTPKtPKGPSSVphosphorylation
down-regulates activity
12058066SIGNOR-216749
CyclinB/CDK1NDUFB6Ser55NKFLENKsPWRKMVHphosphorylation
up-regulates activity
24746669SIGNOR-275598
CyclinB/CDK1AMPHSer272EEPSPLPsPTASPNHphosphorylation
unknown
11113134SIGNOR-250644
CyclinB/CDK1AMBRA1Ser1252QPTLPSSsPVPIPVSphosphorylation
up-regulates activity
37584777SIGNOR-272969
CyclinB/CDK1RANGAP1Ser442STFLAFPsPEKLLRLphosphorylation
up-regulates
15037602SIGNOR-216785
CyclinB/CDK1CDC25BSer160PVRLLGHsPVLRNITphosphorylation
up-regulates
12107172SIGNOR-216753
CyclinB/CDK1NDE1Thr228GPSSSLNtPGSFRRGphosphorylation
up-regulates quantity by stabilization
16682949SIGNOR-274085
CyclinB/CDK1YAP1Ser367GTQNPVSsPGMSQELphosphorylation
up-regulates activity
26933062SIGNOR-276590
CyclinB/CDK1PLECThr4539GGLIEPDtPGRVPLDphosphorylation
down-regulates
19709076SIGNOR-216904
CyclinB/CDK1CDC25CThr130PAQLLCStPNGLDRGphosphorylation
up-regulates
10864927SIGNOR-216769
CyclinB/CDK1ECT2Thr846RAFSFSKtPKRALRRphosphorylation
up-regulates
16247472SIGNOR-216928
CyclinB/CDK1USP24Ser2047QRVSDQNsPVLPKKSphosphorylation
down-regulates quantity by destabilization
27991932SIGNOR-275610
CyclinB/CDK1PBKThr9EGISNFKtPSKLSEKphosphorylation
up-regulates activity
15541388SIGNOR-250720
CyclinB/CDK1LATS1Ser613EKKQITTsPITVRKNphosphorylation
up-regulates
12372621SIGNOR-216757
CyclinB/CDK1TP73Thr86AASASPYtPEHAASVphosphorylation
down-regulates
12676926SIGNOR-216849
CyclinB/CDK1SREBF1Ser439AGSPFQSsPLSLGSRphosphorylation
up-regulates
16880739SIGNOR-216821
CyclinB/CDK1NPM1Thr199VKKSIRDtPAKNAQKphosphorylation
down-regulates activity
12058066SIGNOR-216845
CyclinB/CDK1NDUFV1Thr383HESCGQCtPCREGVDphosphorylation
up-regulates activity
24746669SIGNOR-275602
CyclinB/CDK1BORAphosphorylation
up-regulates activity
18521620SIGNOR-178799
CyclinB/CDK1NDE1Thr215ATGSVPStPIAHRGPphosphorylation
up-regulates quantity by stabilization
16682949SIGNOR-274082
CyclinB/CDK1MCL1Thr92EVPDVTAtPARLLFFphosphorylation
down-regulates quantity by destabilization
18676833SIGNOR-216900
CyclinB/CDK1RANGAP1Thr409GQGEKSAtPSRKILDphosphorylation
up-regulates
15037602SIGNOR-216789
CyclinB/CDK1NDUFB6Thr5tPDEKLRLphosphorylation
up-regulates activity
24746669SIGNOR-275597
CyclinB/CDK1USP24Ser2604HLQQGSEsPMMIGELphosphorylation
down-regulates quantity by destabilization
27991932SIGNOR-275609
CyclinB/CDK1NDUFS2Ser364KVDDAKVsPPKRAEMphosphorylation
up-regulates activity
24746669SIGNOR-275600
CyclinB/CDK1AKAP12Thr767ESFKRLVtPRKKSKSphosphorylation
up-regulates activity
23063527SIGNOR-271840
CyclinB/CDK1UNGSer23ARKRHAPsPEPAVQGphosphorylation
up-regulates activity
18079698SIGNOR-276092
CyclinB/CDK1NDUFA12Thr120HKFNVTGtPEQYVPYphosphorylation
up-regulates activity
24746669SIGNOR-275596
CyclinB/CDK1TSC1Thr1047SSSSELStPEKPPHQphosphorylation
down-regulates
14551205SIGNOR-216949
CyclinB/CDK1PLECThr4539GGLIEPDtPGRVPLDphosphorylation
down-regulates
8626512SIGNOR-216908
CyclinB/CDK1PTPN1Ser386LRGAQAAsPAKGEPSphosphorylation
up-regulates activity
23348582SIGNOR-272971
CyclinB/CDK1NDE1Ser282RNLVYDQsPNRTGGPphosphorylation
up-regulates quantity by stabilization
16682949SIGNOR-274083
CyclinB/CDK1UNGThr60AGQEEPGtPPSSPLSphosphorylation
up-regulates activity
18079698SIGNOR-276095
CyclinB/CDK1DDX3XThr323GCHLLVAtPGRLVDMphosphorylation
down-regulates
16280325SIGNOR-216872
CyclinB/CDK1CLIP1Thr287KIGFPSTtPAKAKANphosphorylation
up-regulates activity
19687009SIGNOR-275471
CyclinB/CDK1NDE1Thr246STGGTPLtPAARISAphosphorylation
up-regulates quantity by stabilization
16682949SIGNOR-274086
CyclinB/CDK1MAPK6Ser688QFHSPVGsPLKSIQAphosphorylation
up-regulates
20236090SIGNOR-216801
CyclinB/CDK1RUNX1Ser21TPPSTALsPGKMSEAphosphorylation
up-regulates
21059642SIGNOR-216916
CyclinB/CDK1MYOD1Ser5sPPLRDVDphosphorylation
down-regulates
14749395SIGNOR-216924
CyclinB/CDK1WWTR1Thr346TGENAGQtPMNINPQphosphorylation
down-regulates activity
26375055SIGNOR-276525
CyclinB/CDK1KAT5Ser86TKNGLPGsRPGSPERphosphorylation
up-regulates activity
12468530SIGNOR-250641
CyclinB/CDK1FOXM1Thr611ETLPISStPSKSVLPphosphorylation
up-regulates
19737929SIGNOR-216837
CyclinB/CDK1SQSTM1Thr269GGKRSRLtPVSPESSphosphorylation
up-regulates
20974803SIGNOR-216936
CyclinB/CDK1MYOD1Ser200YSGDSDAsSPRSNCSphosphorylation
down-regulates
21902831SIGNOR-216860
CyclinB/CDK1KIF22Thr463QGAPLLStPKRERMVphosphorylation
up-regulates
12727876SIGNOR-216793
CyclinB/CDK1DNM1LSer585WRGMLKTSKAEELLAphosphorylation
up-regulates activity
17301055SIGNOR-274131
CyclinB/CDK1KIF4AThr1161FFNPVCAtPNSKILKphosphorylation
up-regulates activity
29771379SIGNOR-265995
CyclinB/CDK1SIRT3Ser159SGIPDFRsPGSGLYSphosphorylation
up-regulates activity
26141949SIGNOR-276921
CyclinB/CDK1UNGSer12KTLYSFFsPSPARKRphosphorylation
up-regulates activity
18079698SIGNOR-276093
CyclinB/CDK1NDE1Thr191QKQEKPRtPMPSSVEphosphorylation
up-regulates quantity by stabilization
16682949SIGNOR-274087
CyclinB/CDK1TSC1Ser584ETSIFTPsPCKIPPPphosphorylation
down-regulates
14551205SIGNOR-216944
CyclinB/CDK1WEE1Ser123EEGFGSSsPVKSPAAphosphorylation
down-regulates quantity by destabilization
23051732SIGNOR-267471
CyclinB/CDK1WWTR1Thr326GCYSVPTtPEDFLSNphosphorylation
down-regulates activity
26375055SIGNOR-276523
CyclinB/CDK1UNGSer14LYSFFSPsPARKRHAphosphorylation
up-regulates activity
18079698SIGNOR-276096
CyclinB/CDK1CDC25CSer122DQHLMKCsPAQLLCSphosphorylation
up-regulates
10864927SIGNOR-216741
CyclinB/CDK1AMBRA1Thr1238ASWDQPGtPGREPTQphosphorylation
up-regulates activity
37584777SIGNOR-272967
CyclinB/CDK1MASTLThr194NMMDILTtPSMAKPRphosphorylation
up-regulates activity
22354989SIGNOR-243403
CyclinB/CDK1AMPHSer276PLPSPTAsPNHTLAPphosphorylation
unknown
11113134SIGNOR-250645
CyclinB/CDK1FERMT1Ser176SSPTASGsSVSPGLYphosphorylation
down-regulates quantity by destabilization
35469017SIGNOR-276720
CyclinB/CDK1ECT2Thr373VSMLSLNtPNSNRKRphosphorylation
down-regulates
16170345SIGNOR-216864
CyclinB/CDK1MAPK6Ser684IGIPQFHsPVGSPLKphosphorylation
up-regulates
20236090SIGNOR-216797
CyclinB/CDK1SP1Thr739SEGSGTAtPSALITTphosphorylation
up-regulates
20150555SIGNOR-216940
CyclinB/CDK1NDUFA12Thr142QEWIPPStPYKphosphorylation
up-regulates activity
24746669SIGNOR-275595
CyclinB/CDK1WWTR1Ser105TGAGAAGsPAQQHAHphosphorylation
down-regulates activity
26375055SIGNOR-276524
CyclinB/CDK1MTHFRThr34KDSSRCStPGLDPERphosphorylation
down-regulates activity
24769206SIGNOR-263888
CyclinB/CDK1TSC1Thr417SLPQATVtPPRKEERphosphorylation
down-regulates
14551205SIGNOR-216953
CyclinB/CDK1CC2D1ASer208PASTPTYsPAPTQPAphosphorylation
up-regulates activity
20171170SIGNOR-268296
CyclinB/CDK1UNGSer64EPGTPPSsPLSAEQLphosphorylation
up-regulates activity
18079698SIGNOR-276094
CyclinB/CDK1MAPK6Ser705TPSAMKSsPQIPHQTphosphorylation
up-regulates
20236090SIGNOR-216805
CyclinB/CDK1CASP9Thr125PEVLRPEtPRPVDIGphosphorylation
down-regulates
16287866SIGNOR-216876
CyclinB/CDK1CDC25CThr67LSILSGGtPKRCLDLphosphorylation
up-regulates
10864927SIGNOR-216777
CyclinB/CDK1ABI1Ser216VPNDYMTsPARLGSQphosphorylation
down-regulates activity
21900237SIGNOR-264452
CyclinB/CDK1SIRT1Ser540HVSEDSSsPERTSPPphosphorylation
up-regulates
19107194SIGNOR-216841
CyclinB/CDK1ERFphosphorylation
down-regulates
7588608SIGNOR-216852
CyclinB/CDK1NDUFB6Ser29WLKDQELsPREPVLPphosphorylation
up-regulates activity
24746669SIGNOR-275599
CyclinB/CDK1MAPK6Thr698KSIQATLtPSAMKSSphosphorylation
up-regulates
20236090SIGNOR-216809
CyclinB/CDK1CDC25CThr48VCPDVPRtPVGKFLGphosphorylation
up-regulates
10864927SIGNOR-216773
CyclinB/CDK1UHRF1Ser639QQEGGFAsPRTGKGKphosphorylation
down-regulates quantity by destabilization
22411829SIGNOR-276408
CyclinB/CDK1PBKThr9EGISNFKtPSKLSEKphosphorylation
unknown
15541388SIGNOR-216896
CyclinB/CDK1RGCCThr111ALLSATVtPQKAKLGphosphorylation
up-regulates activity
11687586SIGNOR-262725
CyclinB/CDK1ZC3HC1Ser395PGLEVPSsPLRKAKRphosphorylation
down-regulates
17389604SIGNOR-216880
CyclinB/CDK1MYOD1Ser200YSGDSDAsSPRSNCSphosphorylation
down-regulates
14749395SIGNOR-216920
CyclinB/CDK1DDX3XThr204LTRYTRPtPVQKHAIphosphorylation
down-regulates
16280325SIGNOR-216868
CyclinB/CDK1USP24Ser1616NSHSPAGsAAISQQDphosphorylation
down-regulates quantity by destabilization
27991932SIGNOR-275611
CyclinB/CDK1MASTLThr207PRQDYSRtPGQVLSLphosphorylation
up-regulates activity
22354989SIGNOR-249652
CyclinB/CDK1KIFC1Ser6sPLLEVKGphosphorylation
up-regulates quantity by stabilization
24510915SIGNOR-266113
CyclinB/CDK1YAP1Ser138SLQLGAVsPGTLTPTphosphorylation
up-regulates activity
26933062SIGNOR-276592
CyclinB/CDK1FERMT1Ser179TASGSSVsPGLYSKTphosphorylation
down-regulates quantity by destabilization
35469017SIGNOR-276721
CyclinB/CDK1IREB2Ser157LQKAGKLsPVKVQPKphosphorylation
down-regulates
18574241SIGNOR-216888
CyclinB/CDK1FERMT1Ser174LESSPTAsGSSVSPGphosphorylation
down-regulates quantity by destabilization
35469017SIGNOR-276719
CyclinB/CDK1TP53BP1Ser1678ITSEEERsPAKRGRKphosphorylation
down-regulates activity
30685087SIGNOR-264444
CyclinB/CDK1CDC25Cphosphorylation
up-regulates activity
10913154SIGNOR-251510
CyclinB/CDK1CDC25CSer214SRSGLYRsPSMPENLphosphorylation
up-regulates
10864927SIGNOR-216765
CyclinB/CDK1YAP1Thr143AVSPGTLtPTGVVSGphosphorylation
up-regulates activity
26933062SIGNOR-276591
CyclinB/CDK1CASP9Thr125PEVLRPEtPRPVDIGphosphorylation
down-regulates
17466630SIGNOR-216884
CyclinB/CDK1KMT5ASer100SKIYSYMsPNKCSGMphosphorylation
up-regulates quantity by stabilization
20966048SIGNOR-216856
CyclinB/CDK1FERMT2Ser177LITPGSGsIYSSPGLphosphorylation
down-regulates quantity by destabilization
35469017SIGNOR-276713
CyclinB/CDK1WWTR1Ser90QHVRSHSsPASLQLGphosphorylation
down-regulates activity
26375055SIGNOR-276522
CyclinB/CDK1GORASP1Ser373FEVSFLDsPGAQAQAphosphorylation
down-regulates activity
15678101SIGNOR-260606
CyclinB/CDK1CDC7Thr376QVAPRAGtPGFRAPEphosphorylation
up-regulates activity
10846177SIGNOR-250643
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CyclinB/CDK1phosphorylation
up-regulates
KAT5
PSer90
phosphorylation
up-regulates
KAT512468530SIGNOR-250642
CyclinB/CDK1phosphorylation
up-regulates
CDC25A
PSer116
phosphorylation
up-regulates
CDC25A12411508SIGNOR-216761
CyclinB/CDK1phosphorylation
up-regulates
CASP8
PSer387
phosphorylation
down-regulates
CASP820937773SIGNOR-216737
CyclinB/CDK1phosphorylation
up-regulates
SQSTM1
PSer272
phosphorylation
up-regulates
SQSTM120974803SIGNOR-216932
CyclinB/CDK1phosphorylation
up-regulates
RUNX1
PSer397
phosphorylation
up-regulates
RUNX121059642SIGNOR-216912
CyclinB/CDK1phosphorylation
up-regulates
NME1
PSer120
phosphorylation
up-regulates
NME118234856SIGNOR-216825
CyclinB/CDK1phosphorylation
up-regulates
FERMT2
PSer186
phosphorylation
down-regulates
FERMT235469017SIGNOR-276714
CyclinB/CDK1phosphorylation
up-regulates
NCOA3
PSer728
phosphorylation
down-regulates
NCOA322163316SIGNOR-216892
CyclinB/CDK1phosphorylation
up-regulates
SIRT3
PThr150
phosphorylation
up-regulates
SIRT326141949SIGNOR-276922
CyclinB/CDK1phosphorylation
up-regulates
USP9X
PSer2547
phosphorylation
up-regulates
USP9X32152317SIGNOR-275612
CyclinB/CDK1phosphorylation
up-regulates
AMPH
PSer285
phosphorylation
down-regulates
AMPH11113134SIGNOR-250646
CyclinB/CDK1phosphorylation
up-regulates
FERMT2
PSer180
phosphorylation
down-regulates
FERMT235469017SIGNOR-276715
CyclinB/CDK1phosphorylation
up-regulates
NPM1
PThr234
phosphorylation
down-regulates
NPM112058066SIGNOR-216745
CyclinB/CDK1phosphorylation
up-regulates
CKAP2
PThr623
phosphorylation
up-regulates
CKAP219369249SIGNOR-216829
CyclinB/CDK1phosphorylation
up-regulates
NDE1
PThr243
phosphorylation
up-regulates
NDE116682949SIGNOR-274084
CyclinB/CDK1phosphorylation
up-regulates
NDUFV3
PSer105
phosphorylation
up-regulates
NDUFV324746669SIGNOR-275601
CyclinB/CDK1phosphorylation
up-regulates
FERMT2
PSer175
phosphorylation
down-regulates
FERMT235469017SIGNOR-276716
CyclinB/CDK1phosphorylation
up-regulates
ARHGEF2
PSer960
phosphorylation
down-regulates
ARHGEF217488622SIGNOR-276060
CyclinB/CDK1phosphorylation
up-regulates
MEF2C
PSer396
phosphorylation
down-regulates
MEF2C16478538SIGNOR-250719
CyclinB/CDK1phosphorylation
up-regulates
RANGAP1
PSer428
phosphorylation
up-regulates
RANGAP115037602SIGNOR-216781
CyclinB/CDK1phosphorylation
up-regulates
FOXM1
PSer251
phosphorylation
up-regulates
FOXM119737929SIGNOR-216833
CyclinB/CDK1phosphorylation
up-regulates
NPM1
PThr237
phosphorylation
down-regulates
NPM112058066SIGNOR-216749
CyclinB/CDK1phosphorylation
up-regulates
NDUFB6
PSer55
phosphorylation
up-regulates
NDUFB624746669SIGNOR-275598
CyclinB/CDK1phosphorylation
up-regulates
AMPH
PSer272
phosphorylation
down-regulates
AMPH11113134SIGNOR-250644
CyclinB/CDK1phosphorylation
up-regulates
AMBRA1
PSer1252
phosphorylation
up-regulates
AMBRA137584777SIGNOR-272969
CyclinB/CDK1phosphorylation
up-regulates
RANGAP1
PSer442
phosphorylation
up-regulates
RANGAP115037602SIGNOR-216785
CyclinB/CDK1phosphorylation
up-regulates
CDC25B
PSer160
phosphorylation
up-regulates
CDC25B12107172SIGNOR-216753
CyclinB/CDK1phosphorylation
up-regulates
NDE1
PThr228
phosphorylation
up-regulates
NDE116682949SIGNOR-274085
CyclinB/CDK1phosphorylation
up-regulates
YAP1
PSer367
phosphorylation
up-regulates
YAP126933062SIGNOR-276590
CyclinB/CDK1phosphorylation
up-regulates
PLEC
PThr4539
phosphorylation
down-regulates
PLEC19709076SIGNOR-216904
CyclinB/CDK1phosphorylation
up-regulates
CDC25C
PThr130
phosphorylation
up-regulates
CDC25C10864927SIGNOR-216769
CyclinB/CDK1phosphorylation
up-regulates
ECT2
PThr846
phosphorylation
up-regulates
ECT216247472SIGNOR-216928
CyclinB/CDK1phosphorylation
up-regulates
USP24
PSer2047
phosphorylation
down-regulates
USP2427991932SIGNOR-275610
CyclinB/CDK1phosphorylation
up-regulates
PBK
PThr9
phosphorylation
up-regulates
PBK15541388SIGNOR-250720
CyclinB/CDK1phosphorylation
up-regulates
LATS1
PSer613
phosphorylation
up-regulates
LATS112372621SIGNOR-216757
CyclinB/CDK1phosphorylation
up-regulates
TP73
PThr86
phosphorylation
down-regulates
TP7312676926SIGNOR-216849
CyclinB/CDK1phosphorylation
up-regulates
SREBF1
PSer439
phosphorylation
up-regulates
SREBF116880739SIGNOR-216821
CyclinB/CDK1phosphorylation
up-regulates
NPM1
PThr199
phosphorylation
down-regulates
NPM112058066SIGNOR-216845
CyclinB/CDK1phosphorylation
up-regulates
NDUFV1
PThr383
phosphorylation
up-regulates
NDUFV124746669SIGNOR-275602
CyclinB/CDK1phosphorylation
up-regulates
NDE1
PThr215
phosphorylation
up-regulates
NDE116682949SIGNOR-274082
CyclinB/CDK1phosphorylation
up-regulates
MCL1
PThr92
phosphorylation
down-regulates
MCL118676833SIGNOR-216900
CyclinB/CDK1phosphorylation
up-regulates
RANGAP1
PThr409
phosphorylation
up-regulates
RANGAP115037602SIGNOR-216789
CyclinB/CDK1phosphorylation
up-regulates
NDUFB6
PThr5
phosphorylation
up-regulates
NDUFB624746669SIGNOR-275597
CyclinB/CDK1phosphorylation
up-regulates
USP24
PSer2604
phosphorylation
down-regulates
USP2427991932SIGNOR-275609
CyclinB/CDK1phosphorylation
up-regulates
NDUFS2
PSer364
phosphorylation
up-regulates
NDUFS224746669SIGNOR-275600
CyclinB/CDK1phosphorylation
up-regulates
AKAP12
PThr767
phosphorylation
up-regulates
AKAP1223063527SIGNOR-271840
CyclinB/CDK1phosphorylation
up-regulates
UNG
PSer23
phosphorylation
up-regulates
UNG18079698SIGNOR-276092
CyclinB/CDK1phosphorylation
up-regulates
NDUFA12
PThr120
phosphorylation
up-regulates
NDUFA1224746669SIGNOR-275596
CyclinB/CDK1phosphorylation
up-regulates
TSC1
PThr1047
phosphorylation
down-regulates
TSC114551205SIGNOR-216949
CyclinB/CDK1phosphorylation
up-regulates
PLEC
PThr4539
phosphorylation
down-regulates
PLEC8626512SIGNOR-216908
CyclinB/CDK1phosphorylation
up-regulates
PTPN1
PSer386
phosphorylation
up-regulates
PTPN123348582SIGNOR-272971
CyclinB/CDK1phosphorylation
up-regulates
NDE1
PSer282
phosphorylation
up-regulates
NDE116682949SIGNOR-274083
CyclinB/CDK1phosphorylation
up-regulates
UNG
PThr60
phosphorylation
up-regulates
UNG18079698SIGNOR-276095
CyclinB/CDK1phosphorylation
up-regulates
DDX3X
PThr323
phosphorylation
down-regulates
DDX3X16280325SIGNOR-216872
CyclinB/CDK1phosphorylation
up-regulates
CLIP1
PThr287
phosphorylation
up-regulates
CLIP119687009SIGNOR-275471
CyclinB/CDK1phosphorylation
up-regulates
NDE1
PThr246
phosphorylation
up-regulates
NDE116682949SIGNOR-274086
CyclinB/CDK1phosphorylation
up-regulates
MAPK6
PSer688
phosphorylation
up-regulates
MAPK620236090SIGNOR-216801
CyclinB/CDK1phosphorylation
up-regulates
RUNX1
PSer21
phosphorylation
up-regulates
RUNX121059642SIGNOR-216916
CyclinB/CDK1phosphorylation
up-regulates
MYOD1
PSer5
phosphorylation
down-regulates
MYOD114749395SIGNOR-216924
CyclinB/CDK1phosphorylation
up-regulates
WWTR1
PThr346
phosphorylation
down-regulates
WWTR126375055SIGNOR-276525
CyclinB/CDK1phosphorylation
up-regulates
KAT5
PSer86
phosphorylation
up-regulates
KAT512468530SIGNOR-250641
CyclinB/CDK1phosphorylation
up-regulates
FOXM1
PThr611
phosphorylation
up-regulates
FOXM119737929SIGNOR-216837
CyclinB/CDK1phosphorylation
up-regulates
SQSTM1
PThr269
phosphorylation
up-regulates
SQSTM120974803SIGNOR-216936
CyclinB/CDK1phosphorylation
up-regulates
MYOD1
PSer200
phosphorylation
down-regulates
MYOD121902831SIGNOR-216860
CyclinB/CDK1phosphorylation
up-regulates
KIF22
PThr463
phosphorylation
up-regulates
KIF2212727876SIGNOR-216793
CyclinB/CDK1phosphorylation
up-regulates
DNM1L
PSer585
phosphorylation
up-regulates
DNM1L17301055SIGNOR-274131
CyclinB/CDK1phosphorylation
up-regulates
KIF4A
PThr1161
phosphorylation
up-regulates
KIF4A29771379SIGNOR-265995
CyclinB/CDK1phosphorylation
up-regulates
SIRT3
PSer159
phosphorylation
up-regulates
SIRT326141949SIGNOR-276921
CyclinB/CDK1phosphorylation
up-regulates
UNG
PSer12
phosphorylation
up-regulates
UNG18079698SIGNOR-276093
CyclinB/CDK1phosphorylation
up-regulates
NDE1
PThr191
phosphorylation
up-regulates
NDE116682949SIGNOR-274087
CyclinB/CDK1phosphorylation
up-regulates
TSC1
PSer584
phosphorylation
down-regulates
TSC114551205SIGNOR-216944
CyclinB/CDK1phosphorylation
up-regulates
WEE1
PSer123
phosphorylation
down-regulates
WEE123051732SIGNOR-267471
CyclinB/CDK1phosphorylation
up-regulates
WWTR1
PThr326
phosphorylation
down-regulates
WWTR126375055SIGNOR-276523
CyclinB/CDK1phosphorylation
up-regulates
UNG
PSer14
phosphorylation
up-regulates
UNG18079698SIGNOR-276096
CyclinB/CDK1phosphorylation
up-regulates
CDC25C
PSer122
phosphorylation
up-regulates
CDC25C10864927SIGNOR-216741
CyclinB/CDK1phosphorylation
up-regulates
AMBRA1
PThr1238
phosphorylation
up-regulates
AMBRA137584777SIGNOR-272967
CyclinB/CDK1phosphorylation
up-regulates
MASTL
PThr194
phosphorylation
up-regulates
MASTL22354989SIGNOR-243403
CyclinB/CDK1phosphorylation
up-regulates
AMPH
PSer276
phosphorylation
down-regulates
AMPH11113134SIGNOR-250645
CyclinB/CDK1phosphorylation
up-regulates
FERMT1
PSer176
phosphorylation
down-regulates
FERMT135469017SIGNOR-276720
CyclinB/CDK1phosphorylation
up-regulates
ECT2
PThr373
phosphorylation
down-regulates
ECT216170345SIGNOR-216864
CyclinB/CDK1phosphorylation
up-regulates
MAPK6
PSer684
phosphorylation
up-regulates
MAPK620236090SIGNOR-216797
CyclinB/CDK1phosphorylation
up-regulates
SP1
PThr739
phosphorylation
up-regulates
SP120150555SIGNOR-216940
CyclinB/CDK1phosphorylation
up-regulates
NDUFA12
PThr142
phosphorylation
up-regulates
NDUFA1224746669SIGNOR-275595
CyclinB/CDK1phosphorylation
up-regulates
WWTR1
PSer105
phosphorylation
down-regulates
WWTR126375055SIGNOR-276524
CyclinB/CDK1phosphorylation
up-regulates
MTHFR
PThr34
phosphorylation
down-regulates
MTHFR24769206SIGNOR-263888
CyclinB/CDK1phosphorylation
up-regulates
TSC1
PThr417
phosphorylation
down-regulates
TSC114551205SIGNOR-216953
CyclinB/CDK1phosphorylation
up-regulates
CC2D1A
PSer208
phosphorylation
up-regulates
CC2D1A20171170SIGNOR-268296
CyclinB/CDK1phosphorylation
up-regulates
UNG
PSer64
phosphorylation
up-regulates
UNG18079698SIGNOR-276094
CyclinB/CDK1phosphorylation
up-regulates
MAPK6
PSer705
phosphorylation
up-regulates
MAPK620236090SIGNOR-216805
CyclinB/CDK1phosphorylation
up-regulates
CASP9
PThr125
phosphorylation
down-regulates
CASP916287866SIGNOR-216876
CyclinB/CDK1phosphorylation
up-regulates
CDC25C
PThr67
phosphorylation
up-regulates
CDC25C10864927SIGNOR-216777
CyclinB/CDK1phosphorylation
up-regulates
ABI1
PSer216
phosphorylation
down-regulates
ABI121900237SIGNOR-264452
CyclinB/CDK1phosphorylation
up-regulates
SIRT1
PSer540
phosphorylation
up-regulates
SIRT119107194SIGNOR-216841
CyclinB/CDK1phosphorylation
up-regulates
NDUFB6
PSer29
phosphorylation
up-regulates
NDUFB624746669SIGNOR-275599
CyclinB/CDK1phosphorylation
up-regulates
MAPK6
PThr698
phosphorylation
up-regulates
MAPK620236090SIGNOR-216809
CyclinB/CDK1phosphorylation
up-regulates
CDC25C
PThr48
phosphorylation
up-regulates
CDC25C10864927SIGNOR-216773
CyclinB/CDK1phosphorylation
up-regulates
UHRF1
PSer639
phosphorylation
down-regulates
UHRF122411829SIGNOR-276408
CyclinB/CDK1phosphorylation
up-regulates
PBK
PThr9
phosphorylation
down-regulates
PBK15541388SIGNOR-216896
CyclinB/CDK1phosphorylation
up-regulates
RGCC
PThr111
phosphorylation
up-regulates
RGCC11687586SIGNOR-262725
CyclinB/CDK1phosphorylation
up-regulates
ZC3HC1
PSer395
phosphorylation
down-regulates
ZC3HC117389604SIGNOR-216880
CyclinB/CDK1phosphorylation
up-regulates
MYOD1
PSer200
phosphorylation
down-regulates
MYOD114749395SIGNOR-216920
CyclinB/CDK1phosphorylation
up-regulates
DDX3X
PThr204
phosphorylation
down-regulates
DDX3X16280325SIGNOR-216868
CyclinB/CDK1phosphorylation
up-regulates
USP24
PSer1616
phosphorylation
down-regulates
USP2427991932SIGNOR-275611
CyclinB/CDK1phosphorylation
up-regulates
MASTL
PThr207
phosphorylation
up-regulates
MASTL22354989SIGNOR-249652
CyclinB/CDK1phosphorylation
up-regulates
KIFC1
PSer6
phosphorylation
up-regulates
KIFC124510915SIGNOR-266113
CyclinB/CDK1phosphorylation
up-regulates
YAP1
PSer138
phosphorylation
up-regulates
YAP126933062SIGNOR-276592
CyclinB/CDK1phosphorylation
up-regulates
FERMT1
PSer179
phosphorylation
down-regulates
FERMT135469017SIGNOR-276721
CyclinB/CDK1phosphorylation
up-regulates
IREB2
PSer157
phosphorylation
down-regulates
IREB218574241SIGNOR-216888
CyclinB/CDK1phosphorylation
up-regulates
FERMT1
PSer174
phosphorylation
down-regulates
FERMT135469017SIGNOR-276719
CyclinB/CDK1phosphorylation
up-regulates
TP53BP1
PSer1678
phosphorylation
down-regulates
TP53BP130685087SIGNOR-264444
CyclinB/CDK1phosphorylation
up-regulates
CDC25C
PSer214
phosphorylation
up-regulates
CDC25C10864927SIGNOR-216765
CyclinB/CDK1phosphorylation
up-regulates
YAP1
PThr143
phosphorylation
up-regulates
YAP126933062SIGNOR-276591
CyclinB/CDK1phosphorylation
up-regulates
CASP9
PThr125
phosphorylation
down-regulates
CASP917466630SIGNOR-216884
CyclinB/CDK1phosphorylation
up-regulates
KMT5A
PSer100
phosphorylation
up-regulates
KMT5A20966048SIGNOR-216856
CyclinB/CDK1phosphorylation
up-regulates
FERMT2
PSer177
phosphorylation
down-regulates
FERMT235469017SIGNOR-276713
CyclinB/CDK1phosphorylation
up-regulates
WWTR1
PSer90
phosphorylation
down-regulates
WWTR126375055SIGNOR-276522
CyclinB/CDK1phosphorylation
up-regulates
GORASP1
PSer373
phosphorylation
down-regulates
GORASP115678101SIGNOR-260606
CyclinB/CDK1phosphorylation
up-regulates
CDC7
PThr376
phosphorylation
up-regulates
CDC710846177SIGNOR-250643
Regulator Mechanism/Effect Target SIGNOR-ID
CyclinB/CDK1phosphorylation

up-regulates activity
KAT5SIGNOR-250642
CyclinB/CDK1phosphorylation

up-regulates
CDC25ASIGNOR-216761
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
CASP8SIGNOR-216737
CyclinB/CDK1phosphorylation

up-regulates
SQSTM1SIGNOR-216932
CyclinB/CDK1phosphorylation

up-regulates
RUNX1SIGNOR-216912
CyclinB/CDK1phosphorylation

up-regulates
NME1SIGNOR-216825
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FERMT2SIGNOR-276714
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
NCOA3SIGNOR-216892
CyclinB/CDK1phosphorylation

up-regulates activity
SIRT3SIGNOR-276922
CyclinB/CDK1phosphorylation

up-regulates activity
USP9XSIGNOR-275612
CyclinB/CDK1phosphorylation

unknown
AMPHSIGNOR-250646
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FERMT2SIGNOR-276715
CyclinB/CDK1phosphorylation

down-regulates activity
NPM1SIGNOR-216745
CyclinB/CDK1phosphorylation

up-regulates
CKAP2SIGNOR-216829
CyclinB/CDK1phosphorylation

up-regulates quantity by stabilization
NDE1SIGNOR-274084
CyclinB/CDK1phosphorylation

up-regulates activity
NDUFV3SIGNOR-275601
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FERMT2SIGNOR-276716
CyclinB/CDK1phosphorylation

down-regulates activity
ARHGEF2SIGNOR-276060
CyclinB/CDK1phosphorylation

down-regulates activity
MEF2CSIGNOR-250719
CyclinB/CDK1phosphorylation

up-regulates
RANGAP1SIGNOR-216781
CyclinB/CDK1phosphorylation

up-regulates
FOXM1SIGNOR-216833
CyclinB/CDK1phosphorylation

down-regulates activity
NPM1SIGNOR-216749
CyclinB/CDK1phosphorylation

up-regulates activity
NDUFB6SIGNOR-275598
CyclinB/CDK1phosphorylation

unknown
AMPHSIGNOR-250644
CyclinB/CDK1phosphorylation

up-regulates activity
AMBRA1SIGNOR-272969
CyclinB/CDK1phosphorylation

up-regulates
RANGAP1SIGNOR-216785
CyclinB/CDK1phosphorylation

up-regulates
CDC25BSIGNOR-216753
CyclinB/CDK1phosphorylation

up-regulates quantity by stabilization
NDE1SIGNOR-274085
CyclinB/CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-276590
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
PLECSIGNOR-216904
CyclinB/CDK1phosphorylation

up-regulates
CDC25CSIGNOR-216769
CyclinB/CDK1phosphorylation

up-regulates
ECT2SIGNOR-216928
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
USP24SIGNOR-275610
CyclinB/CDK1phosphorylation

up-regulates activity
PBKSIGNOR-250720
CyclinB/CDK1phosphorylation

up-regulates
LATS1SIGNOR-216757
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
TP73SIGNOR-216849
CyclinB/CDK1phosphorylation

up-regulates
SREBF1SIGNOR-216821
CyclinB/CDK1phosphorylation

down-regulates activity
NPM1SIGNOR-216845
CyclinB/CDK1phosphorylation

up-regulates activity
NDUFV1SIGNOR-275602
CyclinB/CDK1phosphorylation

up-regulates activity
BORASIGNOR-178799
CyclinB/CDK1phosphorylation

up-regulates quantity by stabilization
NDE1SIGNOR-274082
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
MCL1SIGNOR-216900
CyclinB/CDK1phosphorylation

up-regulates
RANGAP1SIGNOR-216789
CyclinB/CDK1phosphorylation

up-regulates activity
NDUFB6SIGNOR-275597
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
USP24SIGNOR-275609
CyclinB/CDK1phosphorylation

up-regulates activity
NDUFS2SIGNOR-275600
CyclinB/CDK1phosphorylation

up-regulates activity
AKAP12SIGNOR-271840
CyclinB/CDK1phosphorylation

up-regulates activity
UNGSIGNOR-276092
CyclinB/CDK1phosphorylation

up-regulates activity
NDUFA12SIGNOR-275596
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
TSC1SIGNOR-216949
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
PLECSIGNOR-216908
CyclinB/CDK1phosphorylation

up-regulates activity
PTPN1SIGNOR-272971
CyclinB/CDK1phosphorylation

up-regulates quantity by stabilization
NDE1SIGNOR-274083
CyclinB/CDK1phosphorylation

up-regulates activity
UNGSIGNOR-276095
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
DDX3XSIGNOR-216872
CyclinB/CDK1phosphorylation

up-regulates activity
CLIP1SIGNOR-275471
CyclinB/CDK1phosphorylation

up-regulates quantity by stabilization
NDE1SIGNOR-274086
CyclinB/CDK1phosphorylation

up-regulates
MAPK6SIGNOR-216801
CyclinB/CDK1phosphorylation

up-regulates
RUNX1SIGNOR-216916
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
MYOD1SIGNOR-216924
CyclinB/CDK1phosphorylation

down-regulates activity
WWTR1SIGNOR-276525
CyclinB/CDK1phosphorylation

up-regulates activity
KAT5SIGNOR-250641
CyclinB/CDK1phosphorylation

up-regulates
FOXM1SIGNOR-216837
CyclinB/CDK1phosphorylation

up-regulates
SQSTM1SIGNOR-216936
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
MYOD1SIGNOR-216860
CyclinB/CDK1phosphorylation

up-regulates
KIF22SIGNOR-216793
CyclinB/CDK1phosphorylation

up-regulates activity
DNM1LSIGNOR-274131
CyclinB/CDK1phosphorylation

up-regulates activity
KIF4ASIGNOR-265995
CyclinB/CDK1phosphorylation

up-regulates activity
SIRT3SIGNOR-276921
CyclinB/CDK1phosphorylation

up-regulates activity
UNGSIGNOR-276093
CyclinB/CDK1phosphorylation

up-regulates quantity by stabilization
NDE1SIGNOR-274087
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
TSC1SIGNOR-216944
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
WEE1SIGNOR-267471
CyclinB/CDK1phosphorylation

down-regulates activity
WWTR1SIGNOR-276523
CyclinB/CDK1phosphorylation

up-regulates activity
UNGSIGNOR-276096
CyclinB/CDK1phosphorylation

up-regulates
CDC25CSIGNOR-216741
CyclinB/CDK1phosphorylation

up-regulates activity
AMBRA1SIGNOR-272967
CyclinB/CDK1phosphorylation

up-regulates activity
MASTLSIGNOR-243403
CyclinB/CDK1phosphorylation

unknown
AMPHSIGNOR-250645
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FERMT1SIGNOR-276720
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
ECT2SIGNOR-216864
CyclinB/CDK1phosphorylation

up-regulates
MAPK6SIGNOR-216797
CyclinB/CDK1phosphorylation

up-regulates
SP1SIGNOR-216940
CyclinB/CDK1phosphorylation

up-regulates activity
NDUFA12SIGNOR-275595
CyclinB/CDK1phosphorylation

down-regulates activity
WWTR1SIGNOR-276524
CyclinB/CDK1phosphorylation

down-regulates activity
MTHFRSIGNOR-263888
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
TSC1SIGNOR-216953
CyclinB/CDK1phosphorylation

up-regulates activity
CC2D1ASIGNOR-268296
CyclinB/CDK1phosphorylation

up-regulates activity
UNGSIGNOR-276094
CyclinB/CDK1phosphorylation

up-regulates
MAPK6SIGNOR-216805
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
CASP9SIGNOR-216876
CyclinB/CDK1phosphorylation

up-regulates
CDC25CSIGNOR-216777
CyclinB/CDK1phosphorylation

down-regulates activity
ABI1SIGNOR-264452
CyclinB/CDK1phosphorylation

up-regulates
SIRT1SIGNOR-216841
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
ERFSIGNOR-216852
CyclinB/CDK1phosphorylation

up-regulates activity
NDUFB6SIGNOR-275599
CyclinB/CDK1phosphorylation

up-regulates
MAPK6SIGNOR-216809
CyclinB/CDK1phosphorylation

up-regulates
CDC25CSIGNOR-216773
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
UHRF1SIGNOR-276408
CyclinB/CDK1phosphorylation

unknown
PBKSIGNOR-216896
CyclinB/CDK1phosphorylation

up-regulates activity
RGCCSIGNOR-262725
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
ZC3HC1SIGNOR-216880
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
MYOD1SIGNOR-216920
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
DDX3XSIGNOR-216868
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
USP24SIGNOR-275611
CyclinB/CDK1phosphorylation

up-regulates activity
MASTLSIGNOR-249652
CyclinB/CDK1phosphorylation

up-regulates quantity by stabilization
KIFC1SIGNOR-266113
CyclinB/CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-276592
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FERMT1SIGNOR-276721
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
IREB2SIGNOR-216888
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FERMT1SIGNOR-276719
CyclinB/CDK1phosphorylation

down-regulates activity
TP53BP1SIGNOR-264444
CyclinB/CDK1phosphorylation

up-regulates activity
CDC25CSIGNOR-251510
CyclinB/CDK1phosphorylation

up-regulates
CDC25CSIGNOR-216765
CyclinB/CDK1phosphorylation

up-regulates activity
YAP1SIGNOR-276591
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates
CASP9SIGNOR-216884
CyclinB/CDK1phosphorylation

up-regulates quantity by stabilization
KMT5ASIGNOR-216856
CyclinB/CDK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
FERMT2SIGNOR-276713
CyclinB/CDK1phosphorylation

down-regulates activity
WWTR1SIGNOR-276522
CyclinB/CDK1phosphorylation

down-regulates activity
GORASP1SIGNOR-260606
CyclinB/CDK1phosphorylation

up-regulates activity
CDC7SIGNOR-250643