Entity Details

Name CyclinB/CDK1
ID SIGNOR-C17
Role substrate
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDC25CCyclinB/CDK1Tyr15EKIGEGTyGVVYKGRdephosphorylation
up-regulates activity		10913154SIGNOR-255037
CDC25BCyclinB/CDK1–dephosphorylation
up-regulates		7880537SIGNOR-217511
CDC25CCyclinB/CDK1Thr14IEKIGEGtYGVVYKGdephosphorylation
up-regulates activity		10913154SIGNOR-251509
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDC25Cdephosphorylation
down-regulates
⊣
CyclinB/CDK1
PTyr15		dephosphorylation
down-regulates
⊣		CyclinB/CDK110913154SIGNOR-255037
CDC25Cdephosphorylation
down-regulates
⊣
CyclinB/CDK1
PThr14		dephosphorylation
down-regulates
⊣		CyclinB/CDK110913154SIGNOR-251509
Regulator Mechanism/Effect Target SIGNOR-ID
CDC25Cdephosphorylation
→
up-regulates activity 		CyclinB/CDK1SIGNOR-255037
CDC25Bdephosphorylation
→
up-regulates 		CyclinB/CDK1SIGNOR-217511
CDC25Cdephosphorylation
→
up-regulates activity 		CyclinB/CDK1SIGNOR-251509