| Name | CyclinD/CDK4 |
| ID | SIGNOR-C18 |
| Role | kinase |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD/CDK4 | RB1 | Ser780 | STRPPTLsPIPHIPR | phosphorylation down-regulates activity | 23336272 | SIGNOR-216988 |
| CyclinD/CDK4 | RB1 | Ser795 | SPYKFPSsPLRIPGG | phosphorylation down-regulates activity | 23336272 | SIGNOR-216992 |
| CyclinD/CDK4 | RB1 | Ser788 | PIPHIPRsPYKFPSS | phosphorylation down-regulates activity | 9139732 | SIGNOR-250759 |
| CyclinD/CDK4 | RB1 | Thr356 | DSFETQRtPRKSNLD | phosphorylation down-regulates activity | 9139732 | SIGNOR-250760 |
| CyclinD/CDK4 | RB1 | Thr5 | tPRKTAAT | phosphorylation down-regulates activity | 9139732 | SIGNOR-250762 |
| CyclinD/CDK4 | RB1 | Thr826 | LPTPTKMtPRSRILV | phosphorylation down-regulates activity | 9139732 | SIGNOR-216957 |
| CyclinD/CDK4 | UNG | Ser12 | KTLYSFFsPSPARKR | phosphorylation up-regulates activity | 18079698 | SIGNOR-276087 |
| CyclinD/CDK4 | UNG | Ser14 | LYSFFSPsPARKRHA | phosphorylation up-regulates activity | 18079698 | SIGNOR-276085 |
| CyclinD/CDK4 | UNG | Ser23 | ARKRHAPsPEPAVQG | phosphorylation up-regulates activity | 18079698 | SIGNOR-276084 |
| CyclinD/CDK4 | UNG | Thr60 | AGQEEPGtPPSSPLS | phosphorylation up-regulates activity | 18079698 | SIGNOR-276086 |
| CyclinD/CDK4 | UBTF | Ser484 | ERGKLPEsPKRAEEI | phosphorylation up-regulates activity | 10202152 | SIGNOR-250754 |
| CyclinD/CDK4 | CDC25A | Ser40 | ASAAGGLsPVTNLTV | phosphorylation down-regulates quantity by destabilization | 28192398 | SIGNOR-277340 |
| CyclinD/CDK4 | CDC25A | Ser88 | DSGFCLDsPGPLDSK | phosphorylation down-regulates quantity by destabilization | 28192398 | SIGNOR-277342 |
| CyclinD/CDK4 | BRCA1 | Ser632 | LVVSRNLsPPNCTEL | phosphorylation down-regulates | 17334399 | SIGNOR-216984 |
| CyclinD/CDK4 | TSC2 | Ser1217 | MSLENPLsPFSSDIN | phosphorylation up-regulates activity | 32294430 | SIGNOR-274099 |
| CyclinD/CDK4 | TSC2 | Ser1452 | LPSSSPRsPSGLRPR | phosphorylation up-regulates activity | 32294430 | SIGNOR-274100 |
| CyclinD/CDK4 | RUNX3 | Ser356 | SSSGGDRsPTRMLAS | phosphorylation down-regulates | 19351720 | SIGNOR-216980 |
| CyclinD/CDK4 | MEF2D | Ser110 | GEDSLEQsPLLEDKY | phosphorylation down-regulates quantity by destabilization | 25733682 | SIGNOR-276888 |
| CyclinD/CDK4 | MEF2D | Ser98 | KGFNGCDsPEPDGED | phosphorylation down-regulates quantity by destabilization | 25733682 | SIGNOR-276887 |
| CyclinD/CDK4 | KAT2A | Ser372 | EEIYGANsPIWESGF | phosphorylation up-regulates activity | 24870244 | SIGNOR-275496 |
| CyclinD/CDK4 | KAT2A | Thr272 | LNYWKLEtPAQFRQR | phosphorylation up-regulates activity | 24870244 | SIGNOR-275497 |
| CyclinD/CDK4 | RASSF1 | Ser207 | TSVRRRTsFYLPKDA | phosphorylation down-regulates | 18071316 | SIGNOR-216976 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PSer780 | phosphorylation down-regulates ⊣ | RB1 | 23336272 | SIGNOR-216988 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PSer795 | phosphorylation down-regulates ⊣ | RB1 | 23336272 | SIGNOR-216992 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PSer788 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-250759 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PThr356 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-250760 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PThr5 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-250762 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RB1 PThr826 | phosphorylation down-regulates ⊣ | RB1 | 9139732 | SIGNOR-216957 |
| CyclinD/CDK4 | phosphorylation up-regulates → | UNG PSer12 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276087 |
| CyclinD/CDK4 | phosphorylation up-regulates → | UNG PSer14 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276085 |
| CyclinD/CDK4 | phosphorylation up-regulates → | UNG PSer23 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276084 |
| CyclinD/CDK4 | phosphorylation up-regulates → | UNG PThr60 | phosphorylation up-regulates → | UNG | 18079698 | SIGNOR-276086 |
| CyclinD/CDK4 | phosphorylation up-regulates → | UBTF PSer484 | phosphorylation up-regulates → | UBTF | 10202152 | SIGNOR-250754 |
| CyclinD/CDK4 | phosphorylation up-regulates → | CDC25A PSer40 | phosphorylation down-regulates ⊣ | CDC25A | 28192398 | SIGNOR-277340 |
| CyclinD/CDK4 | phosphorylation up-regulates → | CDC25A PSer88 | phosphorylation down-regulates ⊣ | CDC25A | 28192398 | SIGNOR-277342 |
| CyclinD/CDK4 | phosphorylation up-regulates → | BRCA1 PSer632 | phosphorylation down-regulates ⊣ | BRCA1 | 17334399 | SIGNOR-216984 |
| CyclinD/CDK4 | phosphorylation up-regulates → | TSC2 PSer1217 | phosphorylation up-regulates → | TSC2 | 32294430 | SIGNOR-274099 |
| CyclinD/CDK4 | phosphorylation up-regulates → | TSC2 PSer1452 | phosphorylation up-regulates → | TSC2 | 32294430 | SIGNOR-274100 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RUNX3 PSer356 | phosphorylation down-regulates ⊣ | RUNX3 | 19351720 | SIGNOR-216980 |
| CyclinD/CDK4 | phosphorylation up-regulates → | MEF2D PSer110 | phosphorylation down-regulates ⊣ | MEF2D | 25733682 | SIGNOR-276888 |
| CyclinD/CDK4 | phosphorylation up-regulates → | MEF2D PSer98 | phosphorylation down-regulates ⊣ | MEF2D | 25733682 | SIGNOR-276887 |
| CyclinD/CDK4 | phosphorylation up-regulates → | KAT2A PSer372 | phosphorylation up-regulates → | KAT2A | 24870244 | SIGNOR-275496 |
| CyclinD/CDK4 | phosphorylation up-regulates → | KAT2A PThr272 | phosphorylation up-regulates → | KAT2A | 24870244 | SIGNOR-275497 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RASSF1 PSer207 | phosphorylation down-regulates ⊣ | RASSF1 | 18071316 | SIGNOR-216976 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-216988 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-216992 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-250759 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-250760 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-250762 |
| CyclinD/CDK4 | phosphorylation → down-regulates activity | RB1 | SIGNOR-216957 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | UNG | SIGNOR-276087 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | UNG | SIGNOR-276085 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | UNG | SIGNOR-276084 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | UNG | SIGNOR-276086 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | UBTF | SIGNOR-250754 |
| CyclinD/CDK4 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-277340 |
| CyclinD/CDK4 | phosphorylation down-regulates quantity by destabilization | CDC25A | SIGNOR-277342 |
| CyclinD/CDK4 | phosphorylation down-regulates | BRCA1 | SIGNOR-216984 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | TSC2 | SIGNOR-274099 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | TSC2 | SIGNOR-274100 |
| CyclinD/CDK4 | phosphorylation down-regulates | RUNX3 | SIGNOR-216980 |
| CyclinD/CDK4 | phosphorylation down-regulates quantity by destabilization | MEF2D | SIGNOR-276888 |
| CyclinD/CDK4 | phosphorylation down-regulates quantity by destabilization | MEF2D | SIGNOR-276887 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | KAT2A | SIGNOR-275496 |
| CyclinD/CDK4 | phosphorylation → up-regulates activity | KAT2A | SIGNOR-275497 |
| CyclinD/CDK4 | phosphorylation down-regulates | RASSF1 | SIGNOR-216976 |