Entity Details

Name CyclinD/CDK4
ID SIGNOR-C18
Role substrate
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GSK3BCyclinD/CDK4–phosphorylation
down-regulates quantity by destabilization		23552696SIGNOR-245432
CDC25ACyclinD/CDK4–dephosphorylation
up-regulates activity		23429262SIGNOR-245456
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
Regulator Mechanism/Effect Target SIGNOR-ID
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		CyclinD/CDK4SIGNOR-245432
CDC25Adephosphorylation
→
up-regulates activity 		CyclinD/CDK4SIGNOR-245456