| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| mTORC2 | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates | 18925875 | SIGNOR-217016 |
| mTORC2 | ELP1 | Ser1174 | SETSSVVsGSEMSGK | phosphorylation up-regulates activity | 29925953 | SIGNOR-275542 |
| mTORC2 | RRM1 | Ser631 | IYTRRVLsGEFQIVN | phosphorylation up-regulates activity | 34126361 | SIGNOR-277566 |
| mTORC2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-252600 |
| mTORC2 | AKT1 | Thr450 | TAQMITItPPDQDDS | phosphorylation up-regulates activity | 18566586 | SIGNOR-252438 |
| mTORC2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21157483 | SIGNOR-217004 |
| mTORC2 | AKT1 | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 21592956 | SIGNOR-217012 |
| mTORC2 | AKT1 | Ser477 | PQFSYSAsGTA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252441 |
| mTORC2 | AKT1 | Thr479 | FSYSASGtA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252444 |
| mTORC2 | YAP1 | Ser436 | INQSTLPsQQNRFPD | phosphorylation up-regulates activity | 34343821 | SIGNOR-277569 |
| mTORC2 | PRKCE | Thr710 | TREEPVLtLVDEAIV | phosphorylation up-regulates activity | 21806543 | SIGNOR-276347 |
| mTORC2 | FBXW8 | Ser85 | DVASRSRsPLAREGA | phosphorylation up-regulates quantity by stabilization | 23142081 | SIGNOR-271940 |
| mTORC2 | SLC7A11 | Ser26 | NVNGRLPsLGNKEPP | phosphorylation down-regulates activity | 28648777 | SIGNOR-273682 |
| mTORC2 | AMOTL2 | Ser759 | SSSQRAAsLDSVATS | phosphorylation down-regulates activity | 25998128 | SIGNOR-272085 |
| mTORC2 | mTORC2 | – | phosphorylation up-regulates activity | 10702316 | SIGNOR-217000 | |
| mTORC2 | mTORC2 | – | phosphorylation up-regulates activity | 20022946 | SIGNOR-235484 | |
| mTORC2 | AKT | Ser473 | RPHFPQFsYSASGTA | phosphorylation up-regulates activity | 15718470 | SIGNOR-217008 |
| mTORC2 | AKT | Thr450 | TAQMITItPPDQDDS | phosphorylation up-regulates activity | 18566586 | SIGNOR-252448 |
| mTORC2 | AKT | – | phosphorylation up-regulates activity | 21157483 | SIGNOR-251982 | |
| mTORC2 | AKT | – | phosphorylation up-regulates activity | 21592956 | SIGNOR-251983 | |
| mTORC2 | AKT | Ser477 | PQFSYSAsGTA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252451 |
| mTORC2 | AKT | Thr479 | FSYSASGtA | phosphorylation up-regulates activity | 24670654 | SIGNOR-252454 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| mTORC2 | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18925875 | SIGNOR-217016 |
| mTORC2 | phosphorylation up-regulates → | ELP1 PSer1174 | phosphorylation up-regulates → | ELP1 | 29925953 | SIGNOR-275542 |
| mTORC2 | phosphorylation up-regulates → | RRM1 PSer631 | phosphorylation up-regulates → | RRM1 | 34126361 | SIGNOR-277566 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 15718470 | SIGNOR-252600 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PThr450 | phosphorylation up-regulates → | AKT1 | 18566586 | SIGNOR-252438 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21157483 | SIGNOR-217004 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PSer473 | phosphorylation up-regulates → | AKT1 | 21592956 | SIGNOR-217012 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PSer477 | phosphorylation up-regulates → | AKT1 | 24670654 | SIGNOR-252441 |
| mTORC2 | phosphorylation up-regulates → | AKT1 PThr479 | phosphorylation up-regulates → | AKT1 | 24670654 | SIGNOR-252444 |
| mTORC2 | phosphorylation up-regulates → | YAP1 PSer436 | phosphorylation up-regulates → | YAP1 | 34343821 | SIGNOR-277569 |
| mTORC2 | phosphorylation up-regulates → | PRKCE PThr710 | phosphorylation up-regulates → | PRKCE | 21806543 | SIGNOR-276347 |
| mTORC2 | phosphorylation up-regulates → | FBXW8 PSer85 | phosphorylation up-regulates → | FBXW8 | 23142081 | SIGNOR-271940 |
| mTORC2 | phosphorylation up-regulates → | SLC7A11 PSer26 | phosphorylation down-regulates ⊣ | SLC7A11 | 28648777 | SIGNOR-273682 |
| mTORC2 | phosphorylation up-regulates → | AMOTL2 PSer759 | phosphorylation down-regulates ⊣ | AMOTL2 | 25998128 | SIGNOR-272085 |
| mTORC2 | phosphorylation up-regulates → | AKT PSer473 | phosphorylation up-regulates → | AKT | 15718470 | SIGNOR-217008 |
| mTORC2 | phosphorylation up-regulates → | AKT PThr450 | phosphorylation up-regulates → | AKT | 18566586 | SIGNOR-252448 |
| mTORC2 | phosphorylation up-regulates → | AKT PSer477 | phosphorylation up-regulates → | AKT | 24670654 | SIGNOR-252451 |
| mTORC2 | phosphorylation up-regulates → | AKT PThr479 | phosphorylation up-regulates → | AKT | 24670654 | SIGNOR-252454 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| mTORC2 | phosphorylation → up-regulates | SGK1 | SIGNOR-217016 |
| mTORC2 | phosphorylation → up-regulates activity | ELP1 | SIGNOR-275542 |
| mTORC2 | phosphorylation → up-regulates activity | RRM1 | SIGNOR-277566 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252600 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252438 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-217004 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-217012 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252441 |
| mTORC2 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-252444 |
| mTORC2 | phosphorylation → up-regulates activity | YAP1 | SIGNOR-277569 |
| mTORC2 | phosphorylation → up-regulates activity | PRKCE | SIGNOR-276347 |
| mTORC2 | phosphorylation → up-regulates quantity by stabilization | FBXW8 | SIGNOR-271940 |
| mTORC2 | phosphorylation → down-regulates activity | SLC7A11 | SIGNOR-273682 |
| mTORC2 | phosphorylation → down-regulates activity | AMOTL2 | SIGNOR-272085 |
| mTORC2 | phosphorylation → up-regulates activity | mTORC2 | SIGNOR-217000 |
| mTORC2 | phosphorylation → up-regulates activity | mTORC2 | SIGNOR-235484 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-217008 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252448 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-251982 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-251983 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252451 |
| mTORC2 | phosphorylation → up-regulates activity | AKT | SIGNOR-252454 |
